First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 5/13/2021
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Total Number of Holdings (excluding cash): 89

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	191,934	$30,302,539.92	2.13%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	153,059	$29,658,242.43	2.08%
Moderna, Inc.	MRNA	60770K107	Pharmaceuticals and Biotechnology	195,510	$29,301,083.70	2.06%
Anthem, Inc.	ANTM	036752103	Health Care Providers	71,325	$28,205,471.25	1.98%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	135,936	$28,202,641.92	1.98%
PerkinElmer, Inc.	PKI	714046109	Medical Equipment and Services	199,565	$28,192,547.55	1.98%
Cigna Corporation	CI	125523100	Health Care Providers	105,908	$27,959,712.00	1.97%
Humana Inc.	HUM	444859102	Health Care Providers	61,067	$27,843,498.65	1.96%
Laboratory Corporation of America Holdings	LH	50540R409	Medical Equipment and Services	100,388	$27,764,309.16	1.95%
Centene Corporation	CNC	15135B101	Health Care Providers	400,597	$27,396,828.83	1.93%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	199,487	$27,423,477.89	1.93%
Bio-Rad Laboratories, Inc. (Class A)	BIO	090572207	Medical Equipment and Services	44,824	$26,489,639.28	1.86%
The Cooper Companies, Inc.	COO	216648402	Medical Equipment and Services	66,657	$25,854,917.16	1.82%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	91,518	$25,781,535.78	1.81%
Premier, Inc. (Class A)	PINC	74051N102	Health Care Providers	756,340	$25,776,067.20	1.81%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	339,056	$25,602,118.56	1.80%
DaVita Inc.	DVA	23918K108	Health Care Providers	190,050	$23,934,897.00	1.68%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	295,807	$23,688,224.56	1.67%
Sage Therapeutics, Inc.	SAGE	78667J108	Pharmaceuticals and Biotechnology	342,045	$23,755,025.25	1.67%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	1,466,119	$23,355,275.67	1.64%
Molina Healthcare, Inc.	MOH	60855R100	Health Care Providers	87,618	$23,222,274.72	1.63%
Syneos Health, Inc.	SYNH	87166B102	Pharmaceuticals and Biotechnology	270,029	$23,019,972.25	1.62%
PRA Health Sciences, Inc.	PRAH	69354M108	Pharmaceuticals and Biotechnology	133,579	$22,963,565.89	1.61%
Charles River Laboratories International, Inc.	CRL	159864107	Pharmaceuticals and Biotechnology	70,668	$22,685,134.68	1.59%
Jazz Pharmaceuticals Plc	JAZZ	G50871105	Pharmaceuticals and Biotechnology	124,607	$22,199,983.12	1.56%
Hologic, Inc.	HOLX	436440101	Medical Equipment and Services	344,207	$21,616,199.60	1.52%
Avantor, Inc.	AVTR	05352A100	Medical Equipment and Services	707,974	$21,550,728.56	1.51%
Bruker Corporation	BRKR	116794108	Medical Equipment and Services	318,632	$21,517,218.96	1.51%
Bio-Techne Corporation	TECH	09073M104	Medical Equipment and Services	53,627	$21,271,685.82	1.50%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	44,879	$20,506,112.68	1.44%
QIAGEN N.V.	QGEN	N72482123	Medical Equipment and Services	420,655	$19,560,457.50	1.38%
Horizon Therapeutics Plc	HZNP	G46188101	Pharmaceuticals and Biotechnology	222,530	$19,524,782.20	1.37%
Cardinal Health, Inc.	CAH	14149Y108	Pharmaceuticals and Biotechnology	337,147	$18,913,946.70	1.33%
Royalty Pharma Plc- Cl A	RPRX	G7709Q104	Pharmaceuticals and Biotechnology	469,548	$18,866,438.64	1.33%
PPD, Inc.	PPD	69355F102	Medical Equipment and Services	405,953	$18,710,373.77	1.32%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	79,534	$18,265,778.44	1.28%
Acadia Healthcare Company, Inc.	ACHC	00404A109	Health Care Providers	268,836	$17,076,462.72	1.20%
Perrigo Company Plc	PRGO	G97822103	Pharmaceuticals and Biotechnology	379,572	$17,084,535.72	1.20%
UnitedHealth Group Incorporated	UNH	91324P102	Health Care Providers	41,286	$16,867,808.16	1.19%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	187,561	$16,484,736.29	1.16%
Agios Pharmaceuticals, Inc.	AGIO	00847X104	Pharmaceuticals and Biotechnology	297,468	$16,345,866.60	1.15%
Steris Plc	STE	G8473T100	Medical Equipment and Services	80,646	$16,047,747.54	1.13%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	93,467	$15,885,651.32	1.12%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	28,366	$15,703,984.92	1.10%
Merck & Co., Inc.	MRK	58933Y105	Pharmaceuticals and Biotechnology	199,264	$15,680,084.16	1.10%
10X Genomics, Inc. (Class A)	TXG	88025U109	Medical Equipment and Services	113,159	$15,458,650.99	1.09%
Hill-Rom Holdings, Inc.	HRC	431475102	Medical Equipment and Services	139,041	$15,464,140.02	1.09%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	63,176	$15,419,998.08	1.08%
Baxter International Inc.	BAX	071813109	Medical Equipment and Services	182,135	$15,190,059.00	1.07%
Guardant Health, Inc.	GH	40131M109	Pharmaceuticals and Biotechnology	134,174	$14,728,279.98	1.04%
ICU Medical, Inc.	ICUI	44930G107	Medical Equipment and Services	74,772	$14,616,430.56	1.03%
Penumbra, Inc.	PEN	70975L107	Medical Equipment and Services	56,771	$13,670,456.80	0.96%
Repligen Corporation	RGEN	759916109	Medical Equipment and Services	79,015	$13,404,894.75	0.94%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	166,059	$11,844,988.47	0.83%
Alexion Pharmaceuticals, Inc.	ALXN	015351109	Pharmaceuticals and Biotechnology	66,973	$11,608,430.09	0.82%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	45,499	$11,496,232.33	0.81%
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	453,335	$11,537,375.75	0.81%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	282,662	$11,334,746.20	0.80%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	94,630	$11,033,858.00	0.78%
Envista Holdings Corporation	NVST	29415F104	Medical Equipment and Services	251,001	$11,028,983.94	0.78%
Exact Sciences Corporation	EXAS	30063P105	Pharmaceuticals and Biotechnology	116,568	$10,917,758.88	0.77%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	20,929	$10,842,687.03	0.76%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	86,691	$10,766,155.29	0.76%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	54,817	$10,686,025.98	0.75%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	80,548	$10,472,850.96	0.74%
Bristol-Myers Squibb Company	BMY	110122108	Pharmaceuticals and Biotechnology	162,219	$10,550,723.76	0.74%
Integra LifeSciences Holdings Corporation	IART	457985208	Medical Equipment and Services	148,225	$10,472,096.25	0.74%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	85,454	$10,036,572.30	0.71%
Catalent, Inc.	CTLT	148806102	Pharmaceuticals and Biotechnology	97,245	$9,771,177.60	0.69%
Teleflex Incorporated	TFX	879369106	Medical Equipment and Services	24,649	$9,665,119.39	0.68%
Acceleron Pharma Inc.	XLRN	00434H108	Pharmaceuticals and Biotechnology	75,517	$9,312,756.44	0.65%
NovoCure Limited	NVCR	G6674U108	Medical Equipment and Services	38,738	$6,703,223.52	0.47%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	18,172	$5,965,867.60	0.42%
Elanco Animal Health Incorporated	ELAN	28414H103	Pharmaceuticals and Biotechnology	173,868	$5,902,818.60	0.41%
Boston Scientific Corporation	BSX	101137107	Medical Equipment and Services	132,482	$5,512,576.02	0.39%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	32,515	$5,555,187.75	0.39%
DENTSPLY SIRONA Inc.	XRAY	24906P109	Medical Equipment and Services	80,245	$5,345,119.45	0.38%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	79,227	$5,459,532.57	0.38%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	21,022	$5,210,302.70	0.37%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	31,987	$5,298,006.81	0.37%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	20,580	$5,187,600.60	0.36%
Alnylam Pharmaceuticals, Inc.	ALNY	02043Q107	Pharmaceuticals and Biotechnology	36,266	$4,820,476.72	0.34%
Amedisys, Inc.	AMED	023436108	Health Care Providers	19,338	$4,845,135.90	0.34%
Haemonetics Corporation	HAE	405024100	Medical Equipment and Services	92,251	$4,779,524.31	0.34%
Veeva Systems Inc. (Class A)	VEEV	922475108	Health Care Providers	19,600	$4,814,936.00	0.34%
Quidel Corporation	QDEL	74838J101	Medical Equipment and Services	40,025	$4,662,912.50	0.33%
Insulet Corporation	PODD	45784P101	Medical Equipment and Services	19,624	$4,435,416.48	0.31%
ABIOMED, Inc.	ABMD	003654100	Medical Equipment and Services	16,065	$4,220,436.15	0.30%
Teladoc Health, Inc.	TDOC	87918A105	Health Care Providers	28,173	$3,738,838.83	0.26%
US Dollar	$USD		Other	691,157	$691,157.00	0.05%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.