First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 8/22/2025
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Total Number of Holdings (excluding cash): 76

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Insmed Incorporated	INSM	457669307	Pharmaceuticals and Biotechnology	194,761	$25,685,080.68	2.78%
Tempus AI, Inc. (Class A)	TEM	88023B103	Pharmaceuticals and Biotechnology	308,479	$24,838,729.08	2.69%
Elanco Animal Health Incorporated	ELAN	28414H103	Pharmaceuticals and Biotechnology	1,372,610	$24,583,445.10	2.66%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	214,899	$23,146,771.29	2.51%
Jazz Pharmaceuticals Plc	JAZZ	G50871105	Pharmaceuticals and Biotechnology	184,706	$22,739,155.66	2.46%
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	37,333	$22,007,056.84	2.39%
Alnylam Pharmaceuticals, Inc.	ALNY	02043Q107	Pharmaceuticals and Biotechnology	48,086	$21,849,316.68	2.37%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	156,071	$21,742,251.01	2.36%
Merck & Co., Inc.	MRK	58933Y105	Pharmaceuticals and Biotechnology	247,609	$21,633,598.33	2.34%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	68,213	$21,298,144.99	2.31%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	108,204	$20,080,498.32	2.18%
Acadia Healthcare Company, Inc.	ACHC	00404A109	Health Care Providers	863,856	$19,384,928.64	2.10%
Avantor, Inc.	AVTR	05352A100	Medical Equipment and Services	1,456,231	$19,324,185.37	2.09%
Humana Inc.	HUM	444859102	Health Care Providers	64,140	$19,210,571.40	2.08%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	102,656	$18,405,194.24	1.99%
Cardinal Health, Inc.	CAH	14149Y108	Pharmaceuticals and Biotechnology	116,673	$17,279,271.30	1.87%
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	444,716	$17,179,379.08	1.86%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	285,259	$16,710,472.22	1.81%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	646,894	$16,741,616.72	1.81%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	40,930	$16,575,422.10	1.80%
Insulet Corporation	PODD	45784P101	Medical Equipment and Services	49,908	$16,508,069.16	1.79%
Veeva Systems Inc. (Class A)	VEEV	922475108	Health Care Providers	54,452	$15,837,908.72	1.72%
Boston Scientific Corporation	BSX	101137107	Medical Equipment and Services	145,988	$15,499,545.96	1.68%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	92,818	$15,370,660.80	1.67%
UnitedHealth Group Incorporated	UNH	91324P102	Health Care Providers	50,262	$15,451,544.04	1.67%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	115,291	$15,286,433.69	1.66%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	1,619,906	$15,275,713.58	1.66%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	172,694	$14,685,897.76	1.59%
The Cigna Group	CI	125523100	Health Care Providers	47,434	$14,436,537.90	1.56%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	21,927	$14,154,974.85	1.53%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	45,584	$13,389,388.32	1.45%
Doximity, Inc. (Class A)	DOCS	26622P107	Health Care Providers	191,726	$12,987,519.24	1.41%
Teleflex Incorporated	TFX	879369106	Medical Equipment and Services	99,364	$12,859,688.88	1.39%
Elevance Health Inc.	ELV	036752103	Health Care Providers	40,315	$12,761,713.25	1.38%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	134,913	$12,507,784.23	1.36%
Bristol-Myers Squibb Company	BMY	110122108	Pharmaceuticals and Biotechnology	254,064	$12,174,746.88	1.32%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	106,075	$12,174,227.75	1.32%
Tenet Healthcare Corporation	THC	88033G407	Health Care Providers	66,821	$11,994,369.50	1.30%
GE HealthCare Technologies Inc.	GEHC	36266G107	Medical Equipment and Services	158,776	$11,943,130.72	1.29%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	65,471	$11,799,838.33	1.28%
Royalty Pharma Plc (Class A)	RPRX	G7709Q104	Pharmaceuticals and Biotechnology	326,409	$11,855,174.88	1.28%
Corcept Therapeutics Inc.	CORT	218352102	Pharmaceuticals and Biotechnology	160,226	$11,268,694.58	1.22%
Centene Corporation	CNC	15135B101	Health Care Providers	361,107	$10,620,156.87	1.15%
Exact Sciences Corporation	EXAS	30063P105	Pharmaceuticals and Biotechnology	221,311	$10,505,633.17	1.14%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	19,336	$9,667,806.64	1.05%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	49,750	$9,509,712.50	1.03%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	45,516	$9,087,724.56	0.98%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	132,844	$8,305,406.88	0.90%
Labcorp Holdings Inc.	LH	504922105	Medical Equipment and Services	29,866	$8,308,123.88	0.90%
The Cooper Companies, Inc.	COO	216648501	Medical Equipment and Services	110,180	$8,287,739.60	0.90%
Hologic, Inc.	HOLX	436440101	Medical Equipment and Services	120,324	$8,213,316.24	0.89%
Penumbra, Inc.	PEN	70975L107	Medical Equipment and Services	30,550	$8,087,807.00	0.88%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	63,935	$7,853,136.05	0.85%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	19,816	$7,811,863.52	0.85%
Revvity, Inc.	RVTY	714046109	Medical Equipment and Services	81,062	$7,631,987.30	0.83%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	107,330	$7,470,168.00	0.81%
Chemed Corporation	CHE	16359R103	Health Care Providers	16,101	$7,391,164.05	0.80%
Masimo Corporation	MASI	574795100	Medical Equipment and Services	46,608	$6,927,347.04	0.75%
Molina Healthcare, Inc.	MOH	60855R100	Health Care Providers	39,479	$6,886,716.76	0.75%
Intuitive Surgical, Inc.	ISRG	46120E602	Medical Equipment and Services	14,428	$6,870,036.48	0.74%
Halozyme Therapeutics, Inc.	HALO	40637H109	Pharmaceuticals and Biotechnology	70,647	$5,073,867.54	0.55%
Summit Therapeutics Inc.	SMMT	86627T108	Pharmaceuticals and Biotechnology	172,705	$4,524,871.00	0.49%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	16,796	$4,162,888.60	0.45%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	18,607	$3,940,962.60	0.43%
Neurocrine Biosciences, Inc.	NBIX	64125C109	Pharmaceuticals and Biotechnology	29,240	$3,959,973.20	0.43%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	13,165	$3,866,823.80	0.42%
Edwards Lifesciences Corporation	EW	28176E108	Medical Equipment and Services	46,993	$3,845,437.19	0.42%
Steris Plc	STE	G8473T100	Medical Equipment and Services	15,299	$3,853,359.13	0.42%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	31,144	$3,788,044.72	0.41%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	23,565	$3,690,750.30	0.40%
DaVita Inc.	DVA	23918K108	Health Care Providers	25,799	$3,621,147.64	0.39%
Solventum Corporation	SOLV	83444M101	Medical Equipment and Services	48,459	$3,564,159.45	0.39%
DexCom, Inc.	DXCM	252131107	Medical Equipment and Services	42,102	$3,463,310.52	0.38%
Perrigo Company Plc	PRGO	G97822103	Pharmaceuticals and Biotechnology	137,544	$3,368,452.56	0.37%
Waters Corporation	WAT	941848103	Medical Equipment and Services	10,529	$3,181,758.51	0.34%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	19,412	$2,903,452.84	0.31%
US Dollar	$USD		Other	1,816,647	$1,816,646.81	0.20%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.