First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 5/15/2025
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Total Number of Holdings (excluding cash): 76

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	551,320	$25,504,063.20	2.84%
Elanco Animal Health Incorporated	ELAN	28414H103	Pharmaceuticals and Biotechnology	1,938,425	$25,083,219.50	2.80%
Tenet Healthcare Corporation	THC	88033G407	Health Care Providers	150,393	$24,668,963.79	2.75%
Insulet Corporation	PODD	45784P101	Medical Equipment and Services	76,233	$24,548,550.66	2.74%
Cardinal Health, Inc.	CAH	14149Y108	Pharmaceuticals and Biotechnology	146,307	$22,231,348.65	2.48%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	106,824	$20,924,685.12	2.33%
Doximity, Inc. (Class A)	DOCS	26622P107	Health Care Providers	353,712	$20,674,466.40	2.31%
Penumbra, Inc.	PEN	70975L107	Medical Equipment and Services	74,001	$20,373,955.32	2.27%
Centene Corporation	CNC	15135B101	Health Care Providers	331,887	$19,933,133.22	2.22%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	65,381	$19,870,593.52	2.22%
Molina Healthcare, Inc.	MOH	60855R100	Health Care Providers	61,219	$19,220,929.43	2.14%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	151,960	$18,797,452.00	2.10%
Premier, Inc. (Class A)	PINC	74051N102	Health Care Providers	823,935	$18,777,478.65	2.09%
The Cigna Group	CI	125523100	Health Care Providers	60,616	$18,721,857.76	2.09%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	46,422	$17,895,681.00	2.00%
Alnylam Pharmaceuticals, Inc.	ALNY	02043Q107	Pharmaceuticals and Biotechnology	62,751	$17,783,633.40	1.98%
Acadia Healthcare Company, Inc.	ACHC	00404A109	Health Care Providers	670,318	$17,186,953.52	1.92%
Jazz Pharmaceuticals Plc	JAZZ	G50871105	Pharmaceuticals and Biotechnology	160,515	$17,025,826.05	1.90%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	114,118	$17,049,229.20	1.90%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	1,866,299	$16,404,768.21	1.83%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	121,881	$16,252,831.35	1.81%
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	26,011	$15,216,174.89	1.70%
DaVita Inc.	DVA	23918K108	Health Care Providers	105,659	$15,172,632.40	1.69%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	654,043	$14,781,371.80	1.65%
Hologic, Inc.	HOLX	436440101	Medical Equipment and Services	261,486	$14,575,229.64	1.63%
Vertex Pharmaceuticals Incorporated	VRTX	92532F100	Pharmaceuticals and Biotechnology	33,112	$14,383,190.56	1.60%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	118,858	$14,235,622.66	1.59%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	52,296	$14,208,300.24	1.58%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	142,829	$13,815,849.17	1.54%
Intuitive Surgical, Inc.	ISRG	46120E602	Medical Equipment and Services	24,250	$13,586,790.00	1.52%
Avantor, Inc.	AVTR	05352A100	Medical Equipment and Services	1,015,831	$13,043,270.04	1.45%
Royalty Pharma Plc (Class A)	RPRX	G7709Q104	Pharmaceuticals and Biotechnology	386,195	$12,790,778.40	1.43%
Labcorp Holdings Inc.	LH	504922105	Medical Equipment and Services	51,741	$12,742,256.07	1.42%
Veeva Systems Inc. (Class A)	VEEV	922475108	Health Care Providers	52,821	$12,761,553.60	1.42%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	32,249	$12,648,057.80	1.41%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	71,111	$12,544,691.51	1.40%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	174,284	$12,468,277.36	1.39%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	136,033	$11,713,801.63	1.31%
Masimo Corporation	MASI	574795100	Medical Equipment and Services	71,820	$11,088,289.80	1.24%
Chemed Corporation	CHE	16359R103	Health Care Providers	19,457	$11,015,191.41	1.23%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	14,949	$10,961,952.21	1.22%
Elevance Health Inc.	ELV	036752103	Health Care Providers	27,822	$10,850,580.00	1.21%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	58,354	$10,601,754.72	1.18%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	1,135,893	$9,961,781.61	1.11%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	50,771	$9,479,961.12	1.06%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	36,101	$8,973,986.58	1.00%
Steris Plc	STE	G8473T100	Medical Equipment and Services	35,554	$8,777,571.52	0.98%
Edwards Lifesciences Corporation	EW	28176E108	Medical Equipment and Services	111,666	$8,584,882.08	0.96%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	131,749	$8,268,567.24	0.92%
The Cooper Companies, Inc.	COO	216648501	Medical Equipment and Services	98,736	$8,042,047.20	0.90%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	70,362	$7,908,688.80	0.88%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	36,452	$7,679,707.36	0.86%
GE HealthCare Technologies Inc.	GEHC	36266G107	Medical Equipment and Services	100,856	$7,353,410.96	0.82%
Revvity, Inc.	RVTY	714046109	Medical Equipment and Services	76,936	$6,955,014.40	0.78%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	118,122	$6,882,968.94	0.77%
Humana Inc.	HUM	444859102	Health Care Providers	30,315	$6,895,753.05	0.77%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	16,620	$6,729,936.60	0.75%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	46,867	$6,581,532.81	0.73%
UnitedHealth Group Incorporated	UNH	91324P102	Health Care Providers	23,009	$6,312,519.15	0.70%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	35,500	$6,115,585.00	0.68%
DexCom, Inc.	DXCM	252131107	Medical Equipment and Services	55,881	$4,787,325.27	0.53%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	8,988	$4,601,766.12	0.51%
Certara, Inc.	CERT	15687V109	Medical Equipment and Services	381,129	$4,428,718.98	0.49%
Neurocrine Biosciences, Inc.	NBIX	64125C109	Pharmaceuticals and Biotechnology	35,154	$4,227,971.58	0.47%
Medpace Holdings, Inc.	MEDP	58506Q109	Pharmaceuticals and Biotechnology	12,633	$3,744,547.53	0.42%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	23,234	$3,725,571.90	0.42%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	24,551	$3,673,075.11	0.41%
Waters Corporation	WAT	941848103	Medical Equipment and Services	10,567	$3,715,357.20	0.41%
Charles River Laboratories International, Inc.	CRL	159864107	Pharmaceuticals and Biotechnology	25,771	$3,579,334.19	0.40%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	18,769	$3,583,940.55	0.40%
Perrigo Company Plc	PRGO	G97822103	Pharmaceuticals and Biotechnology	135,800	$3,570,182.00	0.40%
Solventum Corporation	SOLV	83444M101	Medical Equipment and Services	49,276	$3,594,191.44	0.40%
Bruker Corporation	BRKR	116794108	Medical Equipment and Services	93,162	$3,418,113.78	0.38%
Teleflex Incorporated	TFX	879369106	Medical Equipment and Services	26,816	$3,391,955.84	0.38%
Bio-Techne Corporation	TECH	09073M104	Medical Equipment and Services	65,590	$3,164,061.60	0.35%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	51,259	$2,963,795.38	0.33%
US Dollar	$USD		Other	690,824	$690,824.17	0.08%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.