First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 12/2/2021
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Total Number of Holdings (excluding cash): 86

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	210,037	$32,412,909.84	2.16%
Molina Healthcare, Inc.	MOH	60855R100	Health Care Providers	112,493	$32,400,233.86	2.15%
Quidel Corporation	QDEL	74838J101	Medical Equipment and Services	216,227	$31,677,255.50	2.11%
Laboratory Corporation of America Holdings	LH	50540R409	Medical Equipment and Services	108,444	$31,586,483.88	2.10%
Bio-Rad Laboratories, Inc. (Class A)	BIO	090572207	Medical Equipment and Services	40,914	$30,612,673.08	2.04%
Hologic, Inc.	HOLX	436440101	Medical Equipment and Services	413,499	$30,503,821.23	2.03%
Cigna Corporation	CI	125523100	Health Care Providers	152,480	$30,159,019.20	2.01%
Catalent, Inc.	CTLT	148806102	Pharmaceuticals and Biotechnology	229,356	$29,277,293.40	1.95%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	125,744	$29,180,152.64	1.94%
Avantor, Inc.	AVTR	05352A100	Medical Equipment and Services	746,222	$29,020,573.58	1.93%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	45,865	$28,662,414.45	1.91%
Repligen Corporation	RGEN	759916109	Medical Equipment and Services	105,612	$28,390,617.84	1.89%
The Cooper Companies, Inc.	COO	216648402	Medical Equipment and Services	73,845	$27,909,717.75	1.86%
Charles River Laboratories International, Inc.	CRL	159864107	Pharmaceuticals and Biotechnology	73,958	$27,065,669.68	1.80%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	315,907	$26,751,004.76	1.78%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	101,930	$26,780,068.90	1.78%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	42,735	$26,819,631.30	1.78%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	220,571	$26,825,845.02	1.78%
Sage Therapeutics, Inc.	SAGE	78667J108	Pharmaceuticals and Biotechnology	688,793	$26,428,987.41	1.76%
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	40,347	$25,579,998.00	1.70%
Bruker Corporation	BRKR	116794108	Medical Equipment and Services	312,629	$25,422,990.28	1.69%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	80,200	$25,348,012.00	1.69%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	132,279	$25,039,091.91	1.67%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	57,513	$25,155,611.07	1.67%
DexCom, Inc.	DXCM	252131107	Medical Equipment and Services	44,649	$25,013,262.78	1.66%
PPD, Inc.	PPD	69355F102	Medical Equipment and Services	521,828	$24,625,063.32	1.64%
Moderna, Inc.	MRNA	60770K107	Pharmaceuticals and Biotechnology	79,304	$23,909,362.96	1.59%
Alnylam Pharmaceuticals, Inc.	ALNY	02043Q107	Pharmaceuticals and Biotechnology	129,318	$23,645,796.30	1.57%
Bio-Techne Corporation	TECH	09073M104	Medical Equipment and Services	50,388	$23,544,800.76	1.57%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	154,994	$23,402,544.06	1.56%
Premier, Inc. (Class A)	PINC	74051N102	Health Care Providers	629,935	$23,339,091.75	1.55%
Horizon Therapeutics Plc	HZNP	G46188101	Pharmaceuticals and Biotechnology	222,899	$23,121,313.27	1.54%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	402,112	$21,328,020.48	1.42%
Syneos Health, Inc.	SYNH	87166B102	Pharmaceuticals and Biotechnology	197,702	$19,503,302.30	1.30%
Novavax, Inc.	NVAX	670002401	Pharmaceuticals and Biotechnology	117,776	$19,076,178.72	1.27%
Royalty Pharma Plc- Cl A	RPRX	G7709Q104	Pharmaceuticals and Biotechnology	478,553	$18,606,140.64	1.24%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	74,854	$18,554,809.52	1.23%
Tandem Diabetes Care, Inc.	TNDM	875372203	Medical Equipment and Services	144,871	$18,481,193.47	1.23%
PerkinElmer, Inc.	PKI	714046109	Medical Equipment and Services	99,803	$17,963,541.97	1.19%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	247,600	$17,250,292.00	1.15%
Intuitive Surgical, Inc.	ISRG	46120E602	Medical Equipment and Services	52,194	$17,084,140.08	1.14%
Edwards Lifesciences Corporation	EW	28176E108	Medical Equipment and Services	152,768	$16,776,981.76	1.12%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	65,624	$16,791,869.12	1.12%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	27,809	$16,657,869.09	1.11%
Amedisys, Inc.	AMED	023436108	Health Care Providers	115,994	$16,427,070.28	1.09%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	227,087	$16,238,991.37	1.08%
Envista Holdings Corporation	NVST	29415F104	Medical Equipment and Services	413,656	$16,136,720.56	1.07%
Seagen Inc.	SGEN	81181C104	Pharmaceuticals and Biotechnology	101,853	$16,161,015.51	1.07%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	527,445	$15,649,293.15	1.04%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	1,276,378	$15,571,811.60	1.04%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	225,723	$14,362,754.49	0.96%
Centene Corporation	CNC	15135B101	Health Care Providers	195,928	$13,993,177.76	0.93%
UnitedHealth Group Incorporated	UNH	91324P102	Health Care Providers	31,244	$13,935,448.88	0.93%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	62,882	$14,034,633.58	0.93%
Vertex Pharmaceuticals Incorporated	VRTX	92532F100	Pharmaceuticals and Biotechnology	67,303	$13,760,098.35	0.92%
Humana Inc.	HUM	444859102	Health Care Providers	31,370	$13,220,572.80	0.88%
Anthem, Inc.	ANTM	036752103	Health Care Providers	32,747	$13,090,285.78	0.87%
QIAGEN N.V.	QGEN	N72482123	Medical Equipment and Services	236,225	$12,888,436.00	0.86%
Masimo Corporation	MASI	574795100	Medical Equipment and Services	45,096	$12,695,876.88	0.84%
Cerner Corporation	CERN	156782104	Health Care Providers	173,117	$12,441,918.79	0.83%
Chemed Corporation	CHE	16359R103	Health Care Providers	26,247	$12,484,123.08	0.83%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	75,593	$11,874,904.37	0.79%
Sarepta Therapeutics, Inc.	SRPT	803607100	Pharmaceuticals and Biotechnology	132,008	$10,981,745.52	0.73%
DENTSPLY SIRONA Inc.	XRAY	24906P109	Medical Equipment and Services	210,305	$10,395,376.15	0.69%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	83,413	$10,253,960.09	0.68%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	109,548	$10,054,315.44	0.67%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	43,140	$9,858,352.80	0.66%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	162,687	$9,489,532.71	0.63%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	48,802	$6,265,200.76	0.42%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	53,444	$6,246,000.28	0.42%
Steris Plc	STE	G8473T100	Medical Equipment and Services	28,222	$6,226,619.86	0.41%
Insulet Corporation	PODD	45784P101	Medical Equipment and Services	20,282	$5,825,801.68	0.39%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	23,452	$5,673,976.88	0.38%
ABIOMED, Inc.	ABMD	003654100	Medical Equipment and Services	17,709	$5,532,999.96	0.37%
ICU Medical, Inc.	ICUI	44930G107	Medical Equipment and Services	24,701	$5,613,055.24	0.37%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	83,817	$5,584,726.71	0.37%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	27,111	$5,453,919.87	0.36%
Baxter International Inc.	BAX	071813109	Medical Equipment and Services	71,677	$5,463,937.71	0.36%
Integra LifeSciences Holdings Corporation	IART	457985208	Medical Equipment and Services	84,186	$5,358,438.90	0.36%
Jazz Pharmaceuticals Plc	JAZZ	G50871105	Pharmaceuticals and Biotechnology	44,273	$5,432,297.10	0.36%
Penumbra, Inc.	PEN	70975L107	Medical Equipment and Services	21,631	$5,355,402.98	0.36%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	21,860	$5,408,164.00	0.36%
Acadia Healthcare Company, Inc.	ACHC	00404A109	Health Care Providers	90,389	$5,173,866.36	0.34%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	45,992	$4,934,021.76	0.33%
DaVita Inc.	DVA	23918K108	Health Care Providers	49,588	$4,877,475.68	0.32%
Mirati Therapeutics, Inc.	MRTX	60468T105	Pharmaceuticals and Biotechnology	32,588	$4,466,511.28	0.30%
US Dollar	$USD		Other	1,036,963	$1,036,962.69	0.07%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.