First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 11/23/2022
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Total Number of Holdings (excluding cash): 83

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Moderna, Inc.	MRNA	60770K107	Pharmaceuticals and Biotechnology	244,934	$43,306,780.54	2.83%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	328,459	$42,584,709.35	2.78%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	3,399,491	$37,462,390.82	2.44%
QuidelOrtho Corporation	QDEL	219798105	Medical Equipment and Services	405,200	$35,718,380.00	2.33%
Laboratory Corporation of America Holdings	LH	50540R409	Medical Equipment and Services	141,419	$33,698,733.51	2.20%
Cigna Corporation	CI	125523100	Health Care Providers	104,386	$33,386,818.24	2.18%
Neurocrine Biosciences, Inc.	NBIX	64125C109	Pharmaceuticals and Biotechnology	272,701	$32,443,237.97	2.12%
Elevance Health Inc.	ELV	036752103	Health Care Providers	63,762	$32,337,535.92	2.11%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	661,875	$32,332,593.75	2.11%
Humana Inc.	HUM	444859102	Health Care Providers	59,696	$32,134,356.80	2.10%
UnitedHealth Group Incorporated	UNH	91324P102	Health Care Providers	57,350	$30,378,868.50	1.98%
Alnylam Pharmaceuticals, Inc.	ALNY	02043Q107	Pharmaceuticals and Biotechnology	144,702	$30,168,919.98	1.97%
Sarepta Therapeutics, Inc.	SRPT	803607100	Pharmaceuticals and Biotechnology	262,020	$30,064,174.80	1.96%
Signify Health, Inc. (Class A)	SGFY	82671G100	Health Care Providers	993,607	$28,417,160.20	1.85%
Molina Healthcare, Inc.	MOH	60855R100	Health Care Providers	87,812	$28,150,770.96	1.84%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	104,155	$27,794,803.30	1.81%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	482,156	$27,227,349.32	1.78%
Ionis Pharmaceuticals, Inc.	IONS	462222100	Pharmaceuticals and Biotechnology	654,843	$27,012,273.75	1.76%
Merck & Co., Inc.	MRK	58933Y105	Pharmaceuticals and Biotechnology	253,226	$27,049,601.32	1.76%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	331,578	$26,658,871.20	1.74%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	177,747	$26,388,319.62	1.72%
Enovis Corp.	ENOV	194014502	Medical Equipment and Services	473,364	$26,030,286.36	1.70%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	327,249	$25,446,882.24	1.66%
Hologic, Inc.	HOLX	436440101	Medical Equipment and Services	338,004	$25,140,737.52	1.64%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	67,444	$24,395,843.68	1.59%
DENTSPLY SIRONA Inc.	XRAY	24906P109	Medical Equipment and Services	769,238	$23,830,993.24	1.55%
Vertex Pharmaceuticals Incorporated	VRTX	92532F100	Pharmaceuticals and Biotechnology	75,317	$23,812,222.72	1.55%
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	31,656	$23,278,556.16	1.52%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	94,553	$22,435,535.84	1.46%
Integra LifeSciences Holdings Corporation	IART	457985208	Medical Equipment and Services	410,249	$22,026,268.81	1.44%
Horizon Therapeutics Plc	HZNP	G46188101	Pharmaceuticals and Biotechnology	280,790	$21,769,648.70	1.42%
Premier, Inc. (Class A)	PINC	74051N102	Health Care Providers	642,545	$21,268,239.50	1.39%
QIAGEN N.V.	QGEN	N72482123	Medical Equipment and Services	420,984	$20,586,117.60	1.34%
Repligen Corporation	RGEN	759916109	Medical Equipment and Services	116,551	$20,114,371.58	1.31%
Envista Holdings Corporation	NVST	29415F104	Medical Equipment and Services	529,663	$19,592,234.37	1.28%
Teleflex Incorporated	TFX	879369106	Medical Equipment and Services	86,263	$19,470,421.73	1.27%
Bristol-Myers Squibb Company	BMY	110122108	Pharmaceuticals and Biotechnology	244,454	$19,346,089.56	1.26%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	179,602	$19,041,404.04	1.24%
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	1,108,305	$18,686,022.30	1.22%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	497,670	$18,528,254.10	1.21%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	742,659	$18,425,369.79	1.20%
Penumbra, Inc.	PEN	70975L107	Medical Equipment and Services	91,655	$17,984,544.10	1.17%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	67,280	$17,718,188.00	1.16%
Masimo Corporation	MASI	574795100	Medical Equipment and Services	123,110	$17,607,192.20	1.15%
Elanco Animal Health Incorporated	ELAN	28414H103	Pharmaceuticals and Biotechnology	1,400,337	$17,098,114.77	1.12%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	215,210	$17,005,894.20	1.11%
Syneos Health, Inc.	SYNH	87166B102	Pharmaceuticals and Biotechnology	462,524	$15,744,316.96	1.03%
agilon health, inc.	AGL	00857U107	Health Care Providers	931,165	$15,299,040.95	1.00%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	176,755	$15,098,412.10	0.99%
Tenet Healthcare Corporation	THC	88033G407	Health Care Providers	336,918	$15,164,679.18	0.99%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	89,709	$13,936,293.15	0.91%
Insulet Corporation	PODD	45784P101	Medical Equipment and Services	47,534	$13,909,874.42	0.91%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	48,378	$13,710,325.20	0.89%
Charles River Laboratories International, Inc.	CRL	159864107	Pharmaceuticals and Biotechnology	55,406	$13,357,278.48	0.87%
Chemed Corporation	CHE	16359R103	Health Care Providers	24,977	$12,815,698.70	0.84%
The Cooper Companies, Inc.	COO	216648402	Medical Equipment and Services	41,319	$12,936,978.90	0.84%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	40,838	$12,392,291.10	0.81%
PerkinElmer, Inc.	PKI	714046109	Medical Equipment and Services	90,619	$12,448,332.03	0.81%
Acadia Healthcare Company, Inc.	ACHC	00404A109	Health Care Providers	139,473	$12,072,782.88	0.79%
Avantor, Inc.	AVTR	05352A100	Medical Equipment and Services	556,323	$11,977,634.19	0.78%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	21,499	$11,766,187.71	0.77%
Centene Corporation	CNC	15135B101	Health Care Providers	140,135	$11,719,490.05	0.76%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	49,949	$11,455,303.66	0.75%
DaVita Inc.	DVA	23918K108	Health Care Providers	131,738	$9,523,340.02	0.62%
Intuitive Surgical, Inc.	ISRG	46120E602	Medical Equipment and Services	29,085	$7,691,528.25	0.50%
Ginkgo Bioworks Holdings, Inc. (Class A)	DNA	37611X100	Pharmaceuticals and Biotechnology	3,494,860	$6,919,822.80	0.45%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	40,625	$6,475,218.75	0.42%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	91,523	$6,510,946.22	0.42%
Catalent, Inc.	CTLT	148806102	Pharmaceuticals and Biotechnology	150,690	$6,356,104.20	0.41%
Jazz Pharmaceuticals Plc	JAZZ	G50871105	Pharmaceuticals and Biotechnology	40,905	$6,187,290.30	0.40%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	26,919	$6,199,176.51	0.40%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	52,149	$6,154,103.49	0.40%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	33,373	$5,907,354.73	0.39%
Steris Plc	STE	G8473T100	Medical Equipment and Services	32,787	$5,918,381.37	0.39%
Doximity, Inc. (Class A)	DOCS	26622P107	Health Care Providers	180,411	$5,843,512.29	0.38%
Baxter International Inc.	BAX	071813109	Medical Equipment and Services	101,227	$5,699,080.10	0.37%
ICU Medical, Inc.	ICUI	44930G107	Medical Equipment and Services	36,201	$5,715,775.89	0.37%
NovoCure Limited	NVCR	G6674U108	Pharmaceuticals and Biotechnology	71,755	$5,419,655.15	0.35%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	26,325	$5,167,071.00	0.34%
Amedisys, Inc.	AMED	023436108	Health Care Providers	56,327	$5,139,838.75	0.34%
Guardant Health, Inc.	GH	40131M109	Pharmaceuticals and Biotechnology	101,282	$5,071,189.74	0.33%
Perrigo Company Plc	PRGO	G97822103	Pharmaceuticals and Biotechnology	152,889	$4,971,950.28	0.32%
Maravai LifeSciences Holdings, Inc. (Class A)	MRVI	56600D107	Pharmaceuticals and Biotechnology	213,551	$3,043,101.75	0.20%
US Dollar	$USD		Other	1,511,591	$1,511,590.63	0.10%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.