First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 9/10/2026
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Total Number of Holdings (excluding cash): 73

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	40,139	$31,840,663.14	2.83%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	92,194	$30,068,151.16	2.67%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	168,301	$29,068,948.72	2.58%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	1,039,259	$28,735,511.35	2.55%
Solventum Corporation	SOLV	83444M101	Medical Equipment and Services	324,369	$28,430,942.85	2.53%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	290,693	$26,871,660.92	2.39%
Guardant Health, Inc.	GH	40131M109	Pharmaceuticals and Biotechnology	166,807	$26,527,317.21	2.36%
Tenet Healthcare Corporation	THC	88033G407	Health Care Providers	99,880	$26,314,384.80	2.34%
Centene Corporation	CNC	15135B101	Health Care Providers	389,868	$25,497,367.20	2.27%
Halozyme Therapeutics, Inc.	HALO	40637H109	Pharmaceuticals and Biotechnology	238,732	$25,544,324.00	2.27%
The Cigna Group	CI	125523100	Health Care Providers	90,781	$25,501,290.71	2.27%
Boston Scientific Corporation	BSX	101137107	Medical Equipment and Services	586,349	$25,271,641.90	2.25%
Corcept Therapeutics Inc.	CORT	218352102	Pharmaceuticals and Biotechnology	214,899	$24,696,193.08	2.19%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	316,731	$23,298,732.36	2.07%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	184,853	$22,374,607.12	1.99%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	238,858	$21,884,169.96	1.94%
Axsome Therapeutics, Inc.	AXSM	05464T104	Pharmaceuticals and Biotechnology	102,246	$21,585,664.29	1.92%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	95,882	$21,053,769.56	1.87%
Medline Inc. (Class A)	MDLN	58507V107	Medical Equipment and Services	634,520	$20,552,102.80	1.83%
DaVita Inc.	DVA	23918K108	Health Care Providers	112,477	$20,395,454.41	1.81%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	164,829	$20,320,119.12	1.81%
Elevance Health Inc.	ELV	036752103	Health Care Providers	48,321	$20,127,629.34	1.79%
QIAGEN N.V.	QGEN	N72482156	Pharmaceuticals and Biotechnology	477,884	$20,133,252.93	1.79%
Arrowhead Pharmaceuticals, Inc.	ARWR	04280A100	Pharmaceuticals and Biotechnology	229,236	$18,971,571.36	1.69%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	260,021	$18,945,130.06	1.68%
Ascendis Pharma A/S	ASND	K08588103	Pharmaceuticals and Biotechnology	70,062	$18,302,296.26	1.63%
Doximity, Inc. (Class A)	DOCS	26622P107	Health Care Providers	723,975	$17,889,422.25	1.59%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	99,218	$17,504,039.56	1.56%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	15,585	$17,501,955.00	1.55%
Neurocrine Biosciences, Inc.	NBIX	64125C109	Pharmaceuticals and Biotechnology	110,868	$17,358,602.76	1.54%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	34,483	$17,374,604.38	1.54%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	118,847	$17,210,234.07	1.53%
Bristol-Myers Squibb Company	BMY	110122108	Pharmaceuticals and Biotechnology	260,594	$16,612,867.50	1.48%
Medpace Holdings, Inc.	MEDP	58506Q109	Pharmaceuticals and Biotechnology	28,353	$16,534,335.48	1.47%
Labcorp Holdings Inc.	LH	504922105	Medical Equipment and Services	53,623	$16,460,116.08	1.46%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	70,841	$16,374,188.74	1.45%
Revolution Medicines, Inc.	RVMD	76155X100	Pharmaceuticals and Biotechnology	80,178	$16,304,196.30	1.45%
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	275,963	$15,848,555.09	1.41%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	945,537	$15,487,896.06	1.38%
Steris Plc	STE	G8473T100	Medical Equipment and Services	71,310	$15,149,809.50	1.35%
GE HealthCare Technologies Inc.	GEHC	36266G107	Medical Equipment and Services	234,574	$15,069,033.76	1.34%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	69,490	$14,970,230.70	1.33%
Veeva Systems Inc. (Class A)	VEEV	922475108	Health Care Providers	52,650	$13,740,597.00	1.22%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	48,355	$12,441,741.50	1.11%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	18,634	$11,239,656.12	1.00%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	102,966	$10,642,565.76	0.95%
Ionis Pharmaceuticals, Inc.	IONS	462222100	Pharmaceuticals and Biotechnology	189,366	$10,538,217.90	0.94%
Chemed Corporation	CHE	16359R103	Health Care Providers	20,056	$10,316,806.40	0.92%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	23,967	$10,095,140.07	0.90%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	70,333	$10,066,058.96	0.89%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	111,864	$9,765,727.20	0.87%
Vertex Pharmaceuticals Incorporated	VRTX	92532F100	Pharmaceuticals and Biotechnology	18,807	$9,677,329.92	0.86%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	37,122	$9,466,110.00	0.84%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	690,018	$9,404,945.34	0.84%
Tempus AI, Inc. (Class A)	TEM	88023B103	Pharmaceuticals and Biotechnology	161,279	$9,473,528.46	0.84%
Madrigal Pharmaceuticals, Inc.	MDGL	558868105	Pharmaceuticals and Biotechnology	17,400	$9,276,288.00	0.82%
BridgeBio Pharma, Inc.	BBIO	10806X102	Pharmaceuticals and Biotechnology	125,441	$9,094,472.50	0.81%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	55,389	$8,348,230.08	0.74%
Bio-Rad Laboratories, Inc. (Class A)	BIO	090572207	Medical Equipment and Services	15,904	$5,864,600.00	0.52%
DexCom, Inc.	DXCM	252131107	Medical Equipment and Services	69,365	$5,862,036.15	0.52%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	81,636	$5,347,974.36	0.48%
Illumina, Inc.	ILMN	452327109	Pharmaceuticals and Biotechnology	26,572	$5,348,146.44	0.48%
Merck & Co., Inc.	MRK	58933Y105	Pharmaceuticals and Biotechnology	36,354	$5,260,787.34	0.47%
Revvity, Inc.	RVTY	714046109	Medical Equipment and Services	41,982	$5,077,303.08	0.45%
The Ensign Group, Inc.	ENSG	29358P101	Health Care Providers	29,135	$5,034,236.65	0.45%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	12,898	$4,933,098.06	0.44%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	24,525	$4,917,998.25	0.44%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	18,398	$4,900,307.30	0.44%
Envista Holdings Corporation	NVST	29415F104	Medical Equipment and Services	177,284	$4,586,337.08	0.41%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	8,874	$4,494,947.22	0.40%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	13,015	$4,480,413.75	0.40%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	14,833	$4,005,058.33	0.36%
The Cooper Companies, Inc.	COO	216648501	Medical Equipment and Services	65,137	$3,528,471.29	0.31%
US Dollar	$USD		Other	2,464,612	$2,464,612.29	0.22%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.