First Trust Health Care AlphaDEX® Fund (FXH)

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Holdings

Holdings of the Fund as of 8/25/2026
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Total Number of Holdings (excluding cash): 73

Security Name	Identifier	CUSIP	Classification	Shares / Quantity	Market Value	Weighting
Regeneron Pharmaceuticals, Inc.	REGN	75886F107	Pharmaceuticals and Biotechnology	39,908	$33,265,712.48	2.84%
Natera, Inc.	NTRA	632307104	Medical Equipment and Services	91,664	$30,864,185.44	2.64%
Pfizer Inc.	PFE	717081103	Pharmaceuticals and Biotechnology	1,033,286	$29,520,981.02	2.52%
Solventum Corporation	SOLV	83444M101	Medical Equipment and Services	322,505	$29,544,683.05	2.52%
Universal Health Services, Inc. (Class B)	UHS	913903100	Health Care Providers	167,334	$29,410,623.84	2.51%
Boston Scientific Corporation	BSX	101137107	Medical Equipment and Services	582,979	$29,067,332.94	2.48%
Zimmer Biomet Holdings, Inc.	ZBH	98956P102	Medical Equipment and Services	289,022	$28,971,565.28	2.47%
Guardant Health, Inc.	GH	40131M109	Pharmaceuticals and Biotechnology	165,848	$27,351,652.16	2.34%
Tenet Healthcare Corporation	THC	88033G407	Health Care Providers	99,306	$26,999,315.28	2.31%
Corcept Therapeutics Inc.	CORT	218352102	Pharmaceuticals and Biotechnology	213,664	$26,402,460.48	2.25%
Globus Medical, Inc. (Class A)	GMED	379577208	Medical Equipment and Services	314,911	$26,125,016.56	2.23%
Halozyme Therapeutics, Inc.	HALO	40637H109	Pharmaceuticals and Biotechnology	237,360	$25,948,195.20	2.22%
Centene Corporation	CNC	15135B101	Health Care Providers	387,627	$25,195,755.00	2.15%
The Cigna Group	CI	125523100	Health Care Providers	90,259	$25,211,143.88	2.15%
ResMed Inc.	RMD	761152107	Medical Equipment and Services	95,331	$22,554,361.29	1.93%
Medline Inc. (Class A)	MDLN	58507V107	Medical Equipment and Services	630,873	$22,484,313.72	1.92%
Encompass Health Corporation	EHC	29261A100	Health Care Providers	183,791	$22,080,650.74	1.89%
Medtronic Plc	MDT	G5960L103	Medical Equipment and Services	237,485	$21,644,382.90	1.85%
Incyte Corporation	INCY	45337C102	Pharmaceuticals and Biotechnology	163,882	$21,258,773.04	1.82%
Axsome Therapeutics, Inc.	AXSM	05464T104	Pharmaceuticals and Biotechnology	101,658	$20,888,685.84	1.78%
QIAGEN N.V.	QGEN	N72482156	Pharmaceuticals and Biotechnology	475,138	$20,739,773.71	1.77%
Arrowhead Pharmaceuticals, Inc.	ARWR	04280A100	Pharmaceuticals and Biotechnology	227,919	$20,257,440.72	1.73%
Zoetis Inc.	ZTS	98978V103	Pharmaceuticals and Biotechnology	258,527	$19,981,551.83	1.71%
DaVita Inc.	DVA	23918K108	Health Care Providers	111,831	$19,883,551.80	1.70%
Elevance Health Inc.	ELV	036752103	Health Care Providers	48,043	$19,162,911.41	1.64%
Eli Lilly and Company	LLY	532457108	Pharmaceuticals and Biotechnology	15,495	$19,115,561.70	1.63%
Becton, Dickinson and Company	BDX	075887109	Medical Equipment and Services	98,648	$18,721,417.44	1.60%
Labcorp Holdings Inc.	LH	504922105	Medical Equipment and Services	53,315	$18,003,409.20	1.54%
Doximity, Inc. (Class A)	DOCS	26622P107	Health Care Providers	719,814	$17,808,198.36	1.52%
United Therapeutics Corporation	UTHR	91307C102	Pharmaceuticals and Biotechnology	34,285	$17,777,801.05	1.52%
Ascendis Pharma A/S	ASND	K08588103	Pharmaceuticals and Biotechnology	69,659	$17,623,030.41	1.51%
Bristol-Myers Squibb Company	BMY	110122108	Pharmaceuticals and Biotechnology	259,096	$17,597,800.32	1.50%
Gilead Sciences, Inc.	GILD	375558103	Pharmaceuticals and Biotechnology	118,164	$17,579,258.28	1.50%
Medpace Holdings, Inc.	MEDP	58506Q109	Pharmaceuticals and Biotechnology	28,190	$17,310,351.40	1.48%
GE HealthCare Technologies Inc.	GEHC	36266G107	Medical Equipment and Services	233,226	$17,237,733.66	1.47%
Quest Diagnostics Incorporated	DGX	74834L100	Medical Equipment and Services	70,434	$17,221,817.34	1.47%
Neurocrine Biosciences, Inc.	NBIX	64125C109	Pharmaceuticals and Biotechnology	110,231	$16,906,128.47	1.44%
Revolution Medicines, Inc.	RVMD	76155X100	Pharmaceuticals and Biotechnology	79,717	$16,850,579.46	1.44%
Steris Plc	STE	G8473T100	Medical Equipment and Services	70,900	$16,763,596.00	1.43%
Viatris Inc.	VTRS	92556V106	Pharmaceuticals and Biotechnology	940,103	$15,718,522.16	1.34%
Exelixis, Inc.	EXEL	30161Q104	Pharmaceuticals and Biotechnology	274,377	$15,562,663.44	1.33%
Biogen Inc.	BIIB	09062X103	Pharmaceuticals and Biotechnology	69,091	$15,253,220.07	1.30%
Veeva Systems Inc. (Class A)	VEEV	922475108	Health Care Providers	52,347	$12,918,192.66	1.10%
IQVIA Holdings Inc.	IQV	46266C105	Health Care Providers	48,077	$12,472,135.34	1.07%
Abbott Laboratories	ABT	002824100	Medical Equipment and Services	102,374	$11,888,692.62	1.02%
Ionis Pharmaceuticals, Inc.	IONS	462222100	Pharmaceuticals and Biotechnology	188,278	$11,968,832.46	1.02%
Thermo Fisher Scientific Inc.	TMO	883556102	Medical Equipment and Services	18,527	$11,637,735.05	0.99%
Tempus AI, Inc. (Class A)	TEM	88023B103	Pharmaceuticals and Biotechnology	160,352	$11,020,992.96	0.94%
Chemed Corporation	CHE	16359R103	Health Care Providers	19,941	$10,847,505.18	0.93%
Agilent Technologies, Inc.	A	00846U101	Medical Equipment and Services	69,929	$10,822,911.33	0.92%
Vertex Pharmaceuticals Incorporated	VRTX	92532F100	Pharmaceuticals and Biotechnology	18,699	$10,337,742.15	0.88%
HCA Healthcare, Inc.	HCA	40412C101	Health Care Providers	23,829	$10,216,922.04	0.87%
BridgeBio Pharma, Inc.	BBIO	10806X102	Pharmaceuticals and Biotechnology	124,720	$10,027,488.00	0.86%
Henry Schein, Inc.	HSIC	806407102	Medical Equipment and Services	111,221	$9,970,962.65	0.85%
AbbVie Inc.	ABBV	00287Y109	Pharmaceuticals and Biotechnology	36,909	$9,810,043.11	0.84%
Organon & Co.	OGN	68622V106	Pharmaceuticals and Biotechnology	686,052	$9,433,215.00	0.81%
Madrigal Pharmaceuticals, Inc.	MDGL	558868105	Pharmaceuticals and Biotechnology	17,300	$8,860,368.00	0.76%
Align Technology, Inc.	ALGN	016255101	Medical Equipment and Services	55,071	$8,789,882.31	0.75%
Bio-Rad Laboratories, Inc. (Class A)	BIO	090572207	Medical Equipment and Services	15,813	$6,172,446.42	0.53%
DexCom, Inc.	DXCM	252131107	Medical Equipment and Services	68,966	$6,149,008.56	0.53%
Illumina, Inc.	ILMN	452327109	Pharmaceuticals and Biotechnology	26,419	$5,944,010.81	0.51%
Amgen Inc.	AMGN	031162100	Pharmaceuticals and Biotechnology	12,824	$5,671,285.76	0.48%
Merck & Co., Inc.	MRK	58933Y105	Pharmaceuticals and Biotechnology	36,145	$5,654,885.25	0.48%
BioMarin Pharmaceutical Inc.	BMRN	09061G101	Pharmaceuticals and Biotechnology	81,167	$5,366,762.04	0.46%
Danaher Corporation	DHR	235851102	Medical Equipment and Services	24,384	$5,266,212.48	0.45%
Revvity, Inc.	RVTY	714046109	Medical Equipment and Services	41,741	$5,210,946.44	0.45%
The Ensign Group, Inc.	ENSG	29358P101	Health Care Providers	28,968	$5,185,851.36	0.44%
Johnson & Johnson	JNJ	478160104	Pharmaceuticals and Biotechnology	18,292	$4,996,276.88	0.43%
Stryker Corporation	SYK	863667101	Medical Equipment and Services	14,748	$4,875,541.32	0.42%
Envista Holdings Corporation	NVST	29415F104	Medical Equipment and Services	176,265	$4,841,999.55	0.41%
IDEXX Laboratories, Inc.	IDXX	45168D104	Medical Equipment and Services	8,823	$4,852,738.23	0.41%
The Cooper Companies, Inc.	COO	216648501	Medical Equipment and Services	64,763	$4,730,289.52	0.40%
West Pharmaceutical Services, Inc.	WST	955306105	Medical Equipment and Services	12,940	$4,509,331.20	0.39%
US Dollar	$USD		Other	2,604,503	$2,604,502.66	0.22%

Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.