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Total Number of Holdings (excluding cash): 50
| Eli Lilly and Company |
LLY |
532457108 |
Pharmaceuticals |
2,347 |
$2,815,062.21 |
7.76% |
| AbbVie Inc. |
ABBV |
00287Y109 |
Pharmaceuticals |
10,640 |
$2,677,449.60 |
7.38% |
| Merck & Co., Inc. |
MRK |
58933Y105 |
Pharmaceuticals |
19,942 |
$2,562,547.00 |
7.07% |
| Johnson & Johnson |
JNJ |
478160104 |
Pharmaceuticals |
9,939 |
$2,524,207.83 |
6.96% |
| Bristol-Myers Squibb Company |
BMY |
110122108 |
Pharmaceuticals |
39,590 |
$2,281,175.80 |
6.29% |
| Biogen Inc. |
BIIB |
09062X103 |
Biotechnology |
6,436 |
$1,390,562.16 |
3.83% |
| Viatris Inc. |
VTRS |
92556V106 |
Pharmaceuticals |
82,694 |
$1,313,180.72 |
3.62% |
| Cardinal Health, Inc. |
CAH |
14149Y108 |
Drug Retailers |
5,386 |
$1,279,498.16 |
3.53% |
| Vertex Pharmaceuticals Incorporated |
VRTX |
92532F100 |
Pharmaceuticals |
2,485 |
$1,234,374.05 |
3.40% |
| Amgen Inc. |
AMGN |
031162100 |
Pharmaceuticals |
3,181 |
$1,151,903.72 |
3.18% |
| Pfizer Inc. |
PFE |
717081103 |
Pharmaceuticals |
44,652 |
$1,075,220.16 |
2.97% |
| Gilead Sciences, Inc. |
GILD |
375558103 |
Pharmaceuticals |
8,289 |
$1,047,232.26 |
2.89% |
| Regeneron Pharmaceuticals, Inc. |
REGN |
75886F107 |
Biotechnology |
1,579 |
$984,569.66 |
2.72% |
| United Therapeutics Corporation |
UTHR |
91307C102 |
Pharmaceuticals |
1,822 |
$987,214.26 |
2.72% |
| Jazz Pharmaceuticals Plc |
JAZZ |
G50871105 |
Pharmaceuticals |
3,741 |
$901,468.77 |
2.49% |
| Incyte Corporation |
INCY |
45337C102 |
Biotechnology |
7,648 |
$866,977.28 |
2.39% |
| Illumina, Inc. |
ILMN |
452327109 |
Biotechnology |
4,088 |
$718,793.04 |
1.98% |
| Zoetis Inc. |
ZTS |
98978V103 |
Pharmaceuticals |
9,417 |
$676,705.62 |
1.87% |
| Exelixis, Inc. |
EXEL |
30161Q104 |
Biotechnology |
11,488 |
$625,062.08 |
1.72% |
| Charles River Laboratories International, Inc. |
CRL |
159864107 |
Biotechnology |
2,377 |
$539,079.83 |
1.49% |
| Medpace Holdings, Inc. |
MEDP |
58506Q109 |
Biotechnology |
966 |
$511,583.94 |
1.41% |
| Neurocrine Biosciences, Inc. |
NBIX |
64125C109 |
Biotechnology |
2,939 |
$495,324.40 |
1.37% |
| PTC Therapeutics, Inc. |
PTCT |
69366J200 |
Biotechnology |
6,091 |
$496,842.87 |
1.37% |
| Alkermes Plc |
ALKS |
G01767105 |
Pharmaceuticals |
9,366 |
$490,731.61 |
1.35% |
| Halozyme Therapeutics, Inc. |
HALO |
40637H109 |
Biotechnology |
5,593 |
$437,764.11 |
1.21% |
| BioMarin Pharmaceutical Inc. |
BMRN |
09061G101 |
Pharmaceuticals |
7,061 |
$404,030.42 |
1.11% |
| Twist Bioscience Corporation |
TWST |
90184D100 |
Biotechnology |
3,619 |
$372,322.72 |
1.03% |
| Spyre Therapeutics, Inc. |
SYRE |
00773J202 |
Biotechnology |
3,948 |
$350,503.44 |
0.97% |
| Travere Therapeutics, Inc. |
TVTX |
89422G107 |
Pharmaceuticals |
5,700 |
$323,817.00 |
0.89% |
| TG Therapeutics, Inc. |
TGTX |
88322Q108 |
Biotechnology |
5,643 |
$310,026.42 |
0.85% |
| Elanco Animal Health Incorporated |
ELAN |
28414H103 |
Pharmaceuticals |
12,210 |
$300,488.10 |
0.83% |
| 10X Genomics, Inc. (Class A) |
TXG |
88025U109 |
Biotechnology |
7,367 |
$282,450.78 |
0.78% |
| Guardant Health, Inc. |
GH |
40131M109 |
Biotechnology |
1,808 |
$271,254.24 |
0.75% |
| Ligand Pharmaceuticals Inc. (Class B) |
LGND |
53220K504 |
Biotechnology |
856 |
$270,573.04 |
0.75% |
| Arcus Biosciences, Inc. |
RCUS |
03969F109 |
Biotechnology |
8,336 |
$256,998.88 |
0.71% |
| Amneal Pharmaceuticals, Inc. |
AMRX |
03168L105 |
Pharmaceuticals |
14,511 |
$251,185.41 |
0.69% |
| Arrowhead Pharmaceuticals, Inc. |
ARWR |
04280A100 |
Biotechnology |
2,918 |
$237,846.18 |
0.66% |
| Catalyst Pharmaceuticals, Inc. |
CPRX |
14888U101 |
Biotechnology |
7,357 |
$231,230.51 |
0.64% |
| Krystal Biotech, Inc. |
KRYS |
501147102 |
Biotechnology |
616 |
$228,948.72 |
0.63% |
| Protagonist Therapeutics, Inc. |
PTGX |
74366E102 |
Biotechnology |
1,844 |
$226,037.52 |
0.62% |
| Moderna, Inc. |
MRNA |
60770K107 |
Biotechnology |
3,170 |
$221,995.10 |
0.61% |
| Kymera Therapeutics, Inc. |
KYMR |
501575104 |
Biotechnology |
1,859 |
$213,171.53 |
0.59% |
| Mirum Pharmaceuticals, Inc. |
MIRM |
604749101 |
Biotechnology |
1,840 |
$215,408.80 |
0.59% |
| Roivant Sciences Ltd. |
ROIV |
G76279101 |
Biotechnology |
5,868 |
$207,668.52 |
0.57% |
| ACADIA Pharmaceuticals Inc. |
ACAD |
004225108 |
Biotechnology |
6,914 |
$174,924.20 |
0.48% |
| Arcutis Biotherapeutics, Inc. |
ARQT |
03969K108 |
Biotechnology |
6,296 |
$165,081.12 |
0.46% |
| Ionis Pharmaceuticals, Inc. |
IONS |
462222100 |
Pharmaceuticals |
2,093 |
$165,953.97 |
0.46% |
| Alnylam Pharmaceuticals, Inc. |
ALNY |
02043Q107 |
Biotechnology |
510 |
$153,525.30 |
0.42% |
| Supernus Pharmaceuticals, Inc. |
SUPN |
868459108 |
Pharmaceuticals |
3,103 |
$144,320.53 |
0.40% |
| Tarsus Pharmaceuticals, Inc. |
TARS |
87650L103 |
Biotechnology |
2,249 |
$141,552.06 |
0.39% |
| US Dollar |
$USD |
|
Other |
54,752 |
$54,752.07 |
0.15% |
Holdings are subject to change.
The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.
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The information presented is not intended to constitute an investment recommendation for, or advice to, any specific person. By providing this information, First Trust is not undertaking to give advice in any fiduciary capacity within the meaning of ERISA, the Internal Revenue Code or any other regulatory framework. Financial professionals are responsible for evaluating investment risks independently and for exercising independent judgment in determining whether investments are appropriate for their clients.
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