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Health Care Opportunity Portfolio, Series 3
Ticker Symbol: FZLHUX

Ticker Company Name Initial
ABBV AbbVie Inc. 3.33% $105.38
ALXN Alexion Pharmaceuticals, Inc. 3.32% 125.59
AMGN Amgen Inc. 3.31% 191.99
BIIB Biogen Inc. 3.39% 346.75
CELG Celgene Corporation 3.37% 104.55
GILD Gilead Sciences, Inc. 3.35% 80.95
REGN Regeneron Pharmaceuticals, Inc. 3.29% 381.71
Health Care Distributors
ABC AmerisourceBergen Corporation 3.31% 102.81
MCK McKesson Corporation 3.33% 170.60
Health Care Equipment
BSX Boston Scientific Corporation 3.34% 27.82
ISRG Intuitive Surgical, Inc. 3.29% 439.55
SYK Stryker Corporation 3.35% 161.94
ZBH Zimmer Biomet Holdings, Inc. 3.36% 124.51
Health Care Facilities
HCA HCA Healthcare, Inc. 3.32% 91.73
Health Care Services
FMS Fresenius Medical Care AG & Co. KGaA 3.34% 56.38
Health Care Supplies
COO The Cooper Companies, Inc. 3.29% 238.70
Life Sciences Tools & Services
ICLR ICON Plc 3.35% 114.10
PRAH PRA Health Sciences, Inc. 3.36% 94.22
TMO Thermo Fisher Scientific Inc. 3.33% 214.55
Managed Health Care
ANTM Anthem, Inc. 3.31% 250.50
CNC Centene Corporation 3.32% 110.97
CI Cigna Corporation 3.29% 219.79
UNH UnitedHealth Group Incorporated 3.38% 245.21
LLY Eli Lilly and Company 3.35% 84.42
JNJ Johnson & Johnson 3.34% 141.83
MRK Merck & Co., Inc. 3.33% 61.70
NVO Novo Nordisk A/S 3.33% 57.94
PFE Pfizer Inc. 3.34% 36.82
RHHBY Roche Holding AG 3.33% 30.66
ZTS Zoetis Inc. 3.35% 77.59

* As of the close of business on 1/23/18.
Market values are for reference only and are not indicative of your individual cost basis.

Not FDIC Insured • Not Bank Guaranteed • May Lose Value

Portfolio Summary
Initial Date of Deposit 1/24/2018
Initial Public Offering Price $10.00 per Unit
Portfolio Ending Date 4/24/2019
Cash CUSIP 30306X782
Reinvestment CUSIP 30306X790
Fee Accounts Cash CUSIP 30306X808
Fee Accounts Reinvestment CUSIP 30306X816

Sales Charges (based on a $10 public offering price)
Standard Accounts
Transactional Sales Charges: Initial: 0.00%
  Deferred: 1.35%
Creation and Development Fee:   0.50%
Maximum Sales Charge:   1.85%

The deferred sales charge will be deducted in three monthly installments commencing 5/18/18.

When the public offering price is less than or equal to $10.00 per unit, there will be no initial sales charge. If the price exceeds $10.00 per unit, you will pay an initial sales charge.

Fee/Wrap Accounts
Maximum Sales Charge: 0.50%

The maximum sales charge for investors in fee accounts consists of the creation and development fee. Investors in fee accounts are not assessed any transactional sales charges. Standard accounts sales charges apply to units purchased as an ineligible asset.

The creation and development fee is a charge of $.050 per unit collected at the end of the initial offering period. If the price you pay exceeds $10 per unit, the creation and development fee will be less than 0.50%; if the price you pay is less than $10 per unit, the creation and development fee will exceed 0.50%.

In addition to the sales charges listed, UITs are subject to annual operating expenses and organization costs.

You should consider the portfolio's investment objective, risks, and charges and expenses carefully before investing. Contact your financial advisor or call First Trust Portfolios, L.P. at 1.800.621.1675 to request a prospectus, which contains this and other information about the portfolio. Read it carefully before you invest.

Risk Considerations:
An investment in this unmanaged unit investment trust should be made with an understanding of the risks involved with owning common stocks, such as an economic recession and the possible deterioration of either the financial condition of the issuers of the equity securities or the general condition of the stock market.

You should be aware that the portfolio is concentrated in stocks in the health care sector which involves additional risks, including limited diversification. The companies engaged in the health care sector are subject to fierce competition, high research and development costs, governmental regulations, loss of patent protection, and changing consumer spending trends.

An investment in a portfolio containing small-cap and mid-cap companies is subject to additional risks, as the share prices of small-cap companies and certain mid-cap companies are often more volatile than those of larger companies due to several factors, including limited trading volumes, products, financial resources, management inexperience and less publicly available information.

An investment in foreign equities should be made with an understanding of the additional risks involved with foreign issuers, such as currency fluctuations, political risk, withholding, the lack of adequate financial information, and exchange control restrictions impacting foreign issuers.

Although this portfolio terminates in approximately 15 months, the strategy is long-term. Investors should consider their ability to pursue investing in successive portfolios, if available. There may be tax consequences unless units are purchased in an IRA or other qualified plan.

The value of the securities held by the trust may be subject to steep declines or increased volatility due to changes in performance or perception of the issuers.

Fund Cusip Information
30306X782 (Cash)
30306X790 (Reinvest)
30306X808 (Cash-Fee)
30306X816 (Reinvest-Fee)
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The information presented is not intended to constitute an investment recommendation for, or advice to, any specific person. By providing this information, First Trust is not undertaking to give advice in any fiduciary capacity within the meaning of ERISA and the Internal Revenue Code. First Trust has no knowledge of and has not been provided any information regarding any investor. Financial advisors must determine whether particular investments are appropriate for their clients. First Trust believes the financial advisor is a fiduciary, is capable of evaluating investment risks independently and is responsible for exercising independent judgment with respect to its retirement plan clients.
First Trust Portfolios L.P.  Member SIPC and FINRA.
First Trust Advisors L.P.
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