First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 7/14/2025

Total Number of Holdings (excluding cash): 76

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 37,773 $21,552,896.07 2.45%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 874,018 $21,046,353.44 2.39%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 157,907 $21,019,000.77 2.38%
Merck & Co., Inc. MRK 58933Y105 Pharmaceuticals and Biotechnology 250,523 $20,961,259.41 2.38%
Jazz Pharmaceuticals Plc JAZZ G50871105 Pharmaceuticals and Biotechnology 186,878 $20,825,684.32 2.36%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 1,388,758 $20,678,606.62 2.35%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 449,948 $20,508,629.84 2.33%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 69,015 $20,544,385.20 2.33%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 217,427 $20,407,698.22 2.32%
Insmed Incorporated INSM 457669307 Pharmaceuticals and Biotechnology 197,053 $20,077,730.17 2.28%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 109,476 $20,083,372.20 2.28%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 1,473,363 $19,477,858.86 2.21%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 118,045 $19,086,696.05 2.17%
Tempus AI, Inc. (Class A) TEM 88023B103 Pharmaceuticals and Biotechnology 312,109 $18,046,142.38 2.05%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Pharmaceuticals and Biotechnology 288,615 $16,806,051.45 1.91%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 654,504 $16,591,676.40 1.88%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 103,864 $16,287,952.48 1.85%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 1,638,964 $16,078,236.84 1.82%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 41,412 $15,755,195.40 1.79%
Veeva Systems Inc. (Class A) VEEV 922475108 Health Care Providers 55,092 $15,551,369.76 1.76%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 116,647 $15,400,903.41 1.75%
Boston Scientific Corporation BSX 101137107 Medical Equipment and Services 147,706 $15,410,166.98 1.75%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 48,652 $15,361,869.00 1.74%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 50,854 $15,285,695.32 1.73%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 93,910 $14,854,683.80 1.69%
Humana Inc. HUM 444859102 Health Care Providers 64,894 $14,760,789.24 1.67%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 50,496 $14,745,336.96 1.67%
The Cigna Group CI 125523100 Health Care Providers 47,992 $14,544,455.52 1.65%
Elevance Health Inc. ELV 036752103 Health Care Providers 40,789 $13,871,115.23 1.57%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 174,726 $12,227,325.48 1.39%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 136,501 $12,248,234.73 1.39%
Bristol-Myers Squibb Company BMY 110122108 Pharmaceuticals and Biotechnology 257,052 $12,168,841.68 1.38%
Exact Sciences Corporation EXAS 30063P105 Pharmaceuticals and Biotechnology 223,915 $12,158,584.50 1.38%
GE HealthCare Technologies Inc. GEHC 36266G107 Medical Equipment and Services 160,644 $11,959,945.80 1.36%
Gilead Sciences, Inc. GILD 375558103 Pharmaceuticals and Biotechnology 107,323 $12,029,835.07 1.36%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 330,249 $11,968,223.76 1.36%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 67,607 $12,016,468.18 1.36%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 193,982 $11,939,592.10 1.35%
Corcept Therapeutics Inc. CORT 218352102 Pharmaceuticals and Biotechnology 162,110 $11,796,744.70 1.34%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 22,185 $11,789,552.70 1.34%
ResMed Inc. RMD 761152107 Medical Equipment and Services 46,120 $11,719,553.20 1.33%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 100,532 $11,636,579.00 1.32%
Centene Corporation CNC 15135B101 Health Care Providers 365,355 $11,194,477.20 1.27%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 66,241 $11,152,997.17 1.27%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 39,943 $8,745,519.85 0.99%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 19,564 $8,321,351.76 0.94%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 46,052 $8,155,348.68 0.93%
The Cooper Companies, Inc. COO 216648501 Medical Equipment and Services 111,476 $8,205,748.36 0.93%
Revvity, Inc. RVTY 714046109 Medical Equipment and Services 82,016 $8,076,115.52 0.92%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 50,336 $8,060,303.68 0.91%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 121,740 $7,866,838.80 0.89%
Stryker Corporation SYK 863667101 Medical Equipment and Services 20,050 $7,848,773.00 0.89%
Encompass Health Corporation EHC 29261A100 Health Care Providers 64,687 $7,741,093.29 0.88%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 134,406 $7,710,872.22 0.87%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 108,592 $7,675,282.56 0.87%
Masimo Corporation MASI 574795100 Medical Equipment and Services 47,156 $7,624,653.64 0.87%
Chemed Corporation CHE 16359R103 Health Care Providers 16,291 $7,573,848.81 0.86%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 14,598 $7,538,991.12 0.86%
Labcorp Holdings Inc. LH 504922105 Medical Equipment and Services 30,218 $7,548,456.40 0.86%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 30,910 $7,397,381.20 0.84%
Summit Therapeutics Inc. SMMT 86627T108 Pharmaceuticals and Biotechnology 174,737 $4,438,319.80 0.50%
Halozyme Therapeutics, Inc. HALO 40637H109 Pharmaceuticals and Biotechnology 71,479 $4,120,764.35 0.47%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 13,319 $3,956,142.57 0.45%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 29,584 $3,997,685.92 0.45%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 19,640 $3,914,448.40 0.44%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 31,510 $3,783,720.80 0.43%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 139,162 $3,814,430.42 0.43%
West Pharmaceutical Services, Inc. WST 955306105 Medical Equipment and Services 16,994 $3,814,983.06 0.43%
Danaher Corporation DHR 235851102 Medical Equipment and Services 18,825 $3,722,643.75 0.42%
DaVita Inc. DVA 23918K108 Health Care Providers 26,103 $3,743,431.23 0.42%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 47,545 $3,721,822.60 0.42%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 23,843 $3,711,162.95 0.42%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 42,598 $3,634,887.34 0.41%
Solventum Corporation SOLV 83444M101 Medical Equipment and Services 49,029 $3,631,578.03 0.41%
Steris Plc STE G8473T100 Medical Equipment and Services 15,479 $3,495,003.41 0.40%
Waters Corporation WAT 941848103 Medical Equipment and Services 10,653 $3,240,429.54 0.37%
US Dollar $USD Other 903,681 $903,681.35 0.10%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.