First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 1/14/2022

Total Number of Holdings (excluding cash): 85

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Cigna Corporation CI 125523100 Health Care Providers 138,419 $33,520,929.23 2.22%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 245,143 $32,768,264.81 2.17%
Sage Therapeutics, Inc. SAGE 78667J108 Pharmaceuticals and Biotechnology 747,186 $32,076,694.98 2.12%
AbbVie Inc. ABBV 00287Y109 Pharmaceuticals and Biotechnology 234,751 $31,895,618.37 2.11%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 123,716 $31,795,012.00 2.10%
The Cooper Companies, Inc. COO 216648402 Medical Equipment and Services 75,871 $31,146,562.92 2.06%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 50,331 $30,965,644.44 2.05%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 63,299 $29,667,608.31 1.96%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 415,169 $28,891,610.71 1.91%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 99,929 $28,589,686.90 1.89%
Viatris Inc. VTRS 92556V106 Pharmaceuticals and Biotechnology 1,879,394 $28,604,376.68 1.89%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 47,637 $28,334,487.60 1.87%
Laboratory Corporation of America Holdings LH 50540R409 Medical Equipment and Services 101,160 $27,928,252.80 1.85%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 112,658 $27,864,829.72 1.84%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 835,080 $27,440,728.80 1.81%
Quidel Corporation QDEL 74838J101 Medical Equipment and Services 235,465 $27,050,219.20 1.79%
Bio-Rad Laboratories, Inc. (Class A) BIO 090572207 Medical Equipment and Services 42,068 $26,428,379.64 1.75%
Envista Holdings Corporation NVST 29415F104 Medical Equipment and Services 564,319 $26,133,612.89 1.73%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 183,719 $26,143,213.70 1.73%
Encompass Health Corporation EHC 29261A100 Health Care Providers 389,644 $25,661,953.84 1.70%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 327,979 $25,510,206.62 1.69%
Tandem Diabetes Care, Inc. TNDM 875372203 Medical Equipment and Services 211,170 $25,500,889.20 1.69%
Gilead Sciences, Inc. GILD 375558103 Pharmaceuticals and Biotechnology 350,203 $25,134,069.31 1.66%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 117,680 $25,178,812.80 1.66%
Premier, Inc. (Class A) PINC 74051N102 Health Care Providers 617,640 $24,452,367.60 1.62%
Steris Plc STE G8473T100 Medical Equipment and Services 104,467 $24,499,600.84 1.62%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 430,622 $23,662,678.90 1.56%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 180,676 $23,155,436.16 1.53%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 603,422 $22,755,043.62 1.50%
Danaher Corporation DHR 235851102 Medical Equipment and Services 77,288 $22,669,343.28 1.50%
Eli Lilly and Company LLY 532457108 Pharmaceuticals and Biotechnology 92,057 $22,472,954.84 1.49%
Syneos Health, Inc. SYNH 87166B102 Pharmaceuticals and Biotechnology 247,646 $22,285,663.54 1.47%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 104,201 $21,484,162.18 1.42%
West Pharmaceutical Services, Inc. WST 955306105 Medical Equipment and Services 54,217 $20,590,532.26 1.36%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Pharmaceuticals and Biotechnology 86,845 $20,326,940.70 1.34%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 184,352 $20,011,409.60 1.32%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 79,489 $19,021,717.70 1.26%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 150,119 $19,122,158.22 1.26%
Anthem, Inc. ANTM 036752103 Health Care Providers 41,142 $18,601,943.88 1.23%
DENTSPLY SIRONA Inc. XRAY 24906P109 Medical Equipment and Services 341,838 $18,438,741.72 1.22%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 147,211 $17,409,172.86 1.15%
Amedisys, Inc. AMED 023436108 Health Care Providers 117,811 $17,293,476.69 1.14%
PerkinElmer, Inc. PKI 714046109 Medical Equipment and Services 94,853 $16,928,414.91 1.12%
QIAGEN N.V. QGEN N72482123 Medical Equipment and Services 343,131 $16,634,990.88 1.10%
Horizon Therapeutics Plc HZNP G46188101 Pharmaceuticals and Biotechnology 176,979 $16,122,786.90 1.07%
Bruker Corporation BRKR 116794108 Medical Equipment and Services 227,281 $16,073,312.32 1.06%
Humana Inc. HUM 444859102 Health Care Providers 41,114 $16,102,709.24 1.06%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 66,376 $15,769,610.08 1.04%
Moderna, Inc. MRNA 60770K107 Pharmaceuticals and Biotechnology 75,089 $15,372,970.97 1.02%
Bio-Techne Corporation TECH 09073M104 Medical Equipment and Services 36,864 $14,381,015.04 0.95%
Repligen Corporation RGEN 759916109 Medical Equipment and Services 72,010 $13,916,652.60 0.92%
Merck & Co., Inc. MRK 58933Y105 Pharmaceuticals and Biotechnology 165,894 $13,500,453.72 0.89%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 56,515 $13,301,370.40 0.88%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 50,557 $13,277,279.34 0.88%
DaVita Inc. DVA 23918K108 Health Care Providers 111,762 $13,000,155.84 0.86%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 176,096 $12,934,251.20 0.86%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 173,217 $12,970,488.96 0.86%
Integra LifeSciences Holdings Corporation IART 457985208 Medical Equipment and Services 189,791 $13,055,722.89 0.86%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 319,049 $12,653,483.34 0.84%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 695,520 $12,602,822.40 0.83%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 74,321 $12,474,036.64 0.82%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 209,457 $12,071,006.91 0.80%
ICU Medical, Inc. ICUI 44930G107 Medical Equipment and Services 53,569 $11,784,644.31 0.78%
Chemed Corporation CHE 16359R103 Health Care Providers 24,033 $11,668,502.16 0.77%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 35,387 $10,889,995.38 0.72%
Catalent, Inc. CTLT 148806102 Pharmaceuticals and Biotechnology 99,306 $10,748,881.44 0.71%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 23,677 $10,591,669.18 0.70%
Maravai LifeSciences Holdings, Inc. (Class A) MRVI 56600D107 Pharmaceuticals and Biotechnology 303,440 $9,203,335.20 0.61%
Jazz Pharmaceuticals Plc JAZZ G50871105 Pharmaceuticals and Biotechnology 49,899 $7,200,425.70 0.48%
Boston Scientific Corporation BSX 101137107 Medical Equipment and Services 149,648 $6,713,209.28 0.44%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 123,463 $6,554,650.67 0.43%
Baxter International Inc. BAX 071813109 Medical Equipment and Services 74,057 $6,349,647.18 0.42%
Cerner Corporation CERN 156782104 Health Care Providers 68,451 $6,311,866.71 0.42%
Stryker Corporation SYK 863667101 Medical Equipment and Services 23,772 $6,340,230.12 0.42%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 19,353 $6,304,239.75 0.42%
Centene Corporation CNC 15135B101 Health Care Providers 77,149 $6,214,351.95 0.41%
ResMed Inc. RMD 761152107 Medical Equipment and Services 24,405 $6,153,964.80 0.41%
Charles River Laboratories International, Inc. CRL 159864107 Pharmaceuticals and Biotechnology 16,872 $5,989,728.72 0.40%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 39,818 $5,760,868.24 0.38%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 37,487 $5,566,819.50 0.37%
ABIOMED, Inc. ABMD 003654100 Medical Equipment and Services 17,700 $5,331,594.00 0.35%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 9,674 $5,075,270.62 0.34%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 9,654 $5,110,344.90 0.34%
Masimo Corporation MASI 574795100 Medical Equipment and Services 21,713 $5,060,866.04 0.33%
Sarepta Therapeutics, Inc. SRPT 803607100 Pharmaceuticals and Biotechnology 70,595 $5,019,304.50 0.33%
US Dollar $USD Other 1,174,976 $1,174,976.09 0.08%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.