First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 2/3/2023

Total Number of Holdings (excluding cash): 83

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Viatris Inc. VTRS 92556V106 Pharmaceuticals and Biotechnology 2,970,385 $36,179,289.30 2.19%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 137,775 $35,556,972.00 2.16%
Laboratory Corporation of America Holdings LH 50540R409 Medical Equipment and Services 140,396 $35,006,338.64 2.12%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 234,655 $34,825,148.55 2.11%
QuidelOrtho Corporation QDEL 219798105 Medical Equipment and Services 385,905 $34,615,678.50 2.10%
Syneos Health, Inc. SYNH 87166B102 Pharmaceuticals and Biotechnology 901,319 $34,187,029.67 2.07%
Exact Sciences Corporation EXAS 30063P105 Pharmaceuticals and Biotechnology 502,778 $33,912,376.10 2.06%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 112,302 $33,150,427.38 2.01%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 139,113 $32,464,800.81 1.97%
Horizon Therapeutics Plc HZNP G46188101 Pharmaceuticals and Biotechnology 290,513 $31,863,465.84 1.93%
Moderna, Inc. MRNA 60770K107 Pharmaceuticals and Biotechnology 184,056 $31,887,702.00 1.93%
Catalent, Inc. CTLT 148806102 Pharmaceuticals and Biotechnology 553,044 $30,998,116.20 1.88%
Elevance Health Inc. ELV 036752103 Health Care Providers 64,450 $30,788,409.50 1.87%
Merck & Co., Inc. MRK 58933Y105 Pharmaceuticals and Biotechnology 297,974 $30,673,443.56 1.86%
Enovis Corp. ENOV 194014502 Medical Equipment and Services 465,107 $30,348,231.75 1.84%
Sarepta Therapeutics, Inc. SRPT 803607100 Pharmaceuticals and Biotechnology 255,136 $30,361,184.00 1.84%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 100,116 $30,141,924.12 1.83%
Cigna Corporation CI 125523100 Health Care Providers 99,778 $29,194,045.02 1.77%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 645,207 $28,427,820.42 1.72%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 332,744 $28,176,761.92 1.71%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 1,551,903 $27,235,897.65 1.65%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 311,663 $27,038,323.64 1.64%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 34,501 $27,018,768.13 1.64%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 335,163 $26,689,029.69 1.62%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 309,916 $25,912,076.76 1.57%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 166,339 $25,707,692.45 1.56%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 89,891 $25,495,784.33 1.55%
Envista Holdings Corporation NVST 29415F104 Medical Equipment and Services 589,137 $24,278,335.77 1.47%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 219,821 $23,835,191.03 1.45%
Premier, Inc. (Class A) PINC 74051N102 Health Care Providers 711,621 $23,711,211.72 1.44%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 89,167 $23,274,370.34 1.41%
Humana Inc. HUM 444859102 Health Care Providers 48,599 $23,160,825.43 1.40%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 406,563 $23,153,762.85 1.40%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 208,411 $22,931,462.33 1.39%
Stryker Corporation SYK 863667101 Medical Equipment and Services 81,133 $22,971,997.62 1.39%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 159,118 $22,723,641.58 1.38%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 1,623,258 $22,514,588.46 1.37%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 89,513 $22,628,886.40 1.37%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 255,227 $22,230,271.70 1.35%
Amedisys, Inc. AMED 023436108 Health Care Providers 237,445 $21,878,182.30 1.33%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 940,551 $21,679,700.55 1.31%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 710,211 $21,135,879.36 1.28%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Pharmaceuticals and Biotechnology 68,689 $20,676,762.78 1.25%
Bristol-Myers Squibb Company BMY 110122108 Pharmaceuticals and Biotechnology 275,694 $20,525,418.30 1.24%
QIAGEN N.V. QGEN N72482123 Medical Equipment and Services 397,758 $19,704,931.32 1.20%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 74,755 $19,038,603.40 1.15%
AbbVie Inc. ABBV 00287Y109 Pharmaceuticals and Biotechnology 122,740 $17,821,848.00 1.08%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 37,414 $17,660,156.28 1.07%
Centene Corporation CNC 15135B101 Health Care Providers 241,875 $17,175,543.75 1.04%
ICU Medical, Inc. ICUI 44930G107 Medical Equipment and Services 79,035 $15,577,008.15 0.94%
Charles River Laboratories International, Inc. CRL 159864107 Pharmaceuticals and Biotechnology 57,120 $14,299,992.00 0.87%
Ionis Pharmaceuticals, Inc. IONS 462222100 Pharmaceuticals and Biotechnology 329,529 $13,484,326.68 0.82%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 365,099 $13,581,682.80 0.82%
Sotera Health Company SHC 83601L102 Medical Equipment and Services 747,073 $13,559,374.95 0.82%
Bruker Corporation BRKR 116794108 Medical Equipment and Services 182,096 $13,205,601.92 0.80%
Integra LifeSciences Holdings Corporation IART 457985208 Medical Equipment and Services 221,977 $13,232,048.97 0.80%
Encompass Health Corporation EHC 29261A100 Health Care Providers 208,097 $12,795,884.53 0.78%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 49,859 $12,887,055.73 0.78%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 113,363 $12,672,849.77 0.77%
Danaher Corporation DHR 235851102 Medical Equipment and Services 46,894 $12,654,345.90 0.77%
PerkinElmer, Inc. PKI 714046109 Medical Equipment and Services 88,762 $12,582,013.50 0.76%
Chemed Corporation CHE 16359R103 Health Care Providers 24,385 $12,435,374.60 0.75%
Signify Health, Inc. (Class A) SGFY 82671G100 Health Care Providers 434,272 $12,381,094.72 0.75%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 151,194 $12,240,666.24 0.74%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 47,388 $11,618,115.96 0.70%
Eli Lilly and Company LLY 532457108 Pharmaceuticals and Biotechnology 34,022 $11,536,179.76 0.70%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 70,457 $11,597,926.77 0.70%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 29,507 $10,123,851.70 0.61%
Certara, Inc. CERT 15687V109 Medical Equipment and Services 387,251 $7,563,012.03 0.46%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 15,254 $7,358,682.14 0.45%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 30,373 $7,203,868.14 0.44%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 185,433 $7,066,851.63 0.43%
Masimo Corporation MASI 574795100 Medical Equipment and Services 42,062 $7,127,405.90 0.43%
Repligen Corporation RGEN 759916109 Medical Equipment and Services 36,756 $7,090,599.96 0.43%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 154,921 $6,938,911.59 0.42%
Novavax, Inc. NVAX 670002401 Pharmaceuticals and Biotechnology 605,362 $6,798,215.26 0.41%
The Cooper Companies, Inc. COO 216648402 Medical Equipment and Services 18,819 $6,671,147.31 0.40%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 11,301 $6,642,275.76 0.40%
Azenta Inc. AZTA 114340102 Medical Equipment and Services 106,889 $6,231,628.70 0.38%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 48,808 $6,318,195.60 0.38%
Gilead Sciences, Inc. GILD 375558103 Pharmaceuticals and Biotechnology 72,488 $6,125,236.00 0.37%
Bio-Techne Corporation TECH 09073M104 Medical Equipment and Services 75,086 $5,943,807.76 0.36%
Baxter International Inc. BAX 071813109 Medical Equipment and Services 122,094 $5,699,347.92 0.35%
US Dollar $USD Other 2,834,988 $2,834,987.84 0.17%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.