First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 6/27/2025

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,167,383 $47,942,511.96 4.76%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 347,755 $43,615,432.10 4.33%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 132,904 $42,905,398.32 4.26%
Illumina, Inc. ILMN 452327109 Health Care 422,578 $40,056,168.62 3.98%
Exelixis, Inc. EXEL 30161Q104 Health Care 894,942 $39,082,117.14 3.88%
Exact Sciences Corporation EXAS 30063P105 Health Care 710,922 $38,140,965.30 3.79%
Incyte Corporation INCY 45337C102 Health Care 555,662 $37,990,610.94 3.77%
Mettler-Toledo International Inc. MTD 592688105 Health Care 30,329 $35,925,913.66 3.57%
Natera, Inc. NTRA 632307104 Health Care 213,458 $35,852,405.68 3.56%
BioNTech SE (ADR) BNTX 09075V102 Health Care 327,398 $34,939,914.56 3.47%
Biogen Inc. BIIB 09062X103 Health Care 274,381 $34,593,956.48 3.43%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,679,981 $34,439,610.50 3.42%
Waters Corporation WAT 941848103 Health Care 97,167 $34,242,622.47 3.40%
Bruker Corporation BRKR 116794108 Health Care 815,286 $34,078,954.80 3.38%
Alkermes Plc ALKS G01767105 Health Care 1,170,387 $33,718,849.47 3.35%
Corcept Therapeutics Inc. CORT 218352102 Health Care 460,514 $33,718,835.08 3.35%
Gilead Sciences, Inc. GILD 375558103 Health Care 304,936 $33,747,267.12 3.35%
BeOne Medicines Ltd. (ADR) ONC 07725L102 Health Care 137,179 $33,087,574.80 3.28%
Moderna, Inc. MRNA 60770K107 Health Care 1,206,124 $32,758,327.84 3.25%
United Therapeutics Corporation UTHR 91307C102 Health Care 112,393 $31,949,958.11 3.17%
Repligen Corporation RGEN 759916109 Health Care 257,206 $31,780,373.36 3.15%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 556,150 $30,682,795.50 3.05%
Amgen Inc. AMGN 031162100 Health Care 110,499 $30,622,587.87 3.04%
argenx SE (ADR) ARGX 04016X101 Health Care 54,396 $30,469,375.44 3.02%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 57,022 $29,708,462.00 2.95%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 65,261 $28,799,679.30 2.86%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 524,819 $27,400,799.99 2.72%
Veracyte, Inc. VCYT 92337F107 Health Care 993,724 $27,208,163.12 2.70%
Krystal Biotech, Inc. KRYS 501147102 Health Care 191,518 $26,598,019.84 2.64%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 619,252 $10,595,401.72 1.05%
US Dollar $USD Other 920,735 $920,734.57 0.09%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.