First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 12/2/2021

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
BioNTech SE (ADR) BNTX 09075V102 Health Care 236,120 $78,743,658.80 4.75%
FibroGen, Inc. FGEN 31572Q808 Health Care 5,293,787 $72,842,509.12 4.39%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 105,667 $66,992,878.00 4.04%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 3,337,860 $66,556,928.40 4.01%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 321,349 $65,699,803.05 3.96%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 770,108 $65,212,745.44 3.93%
IQVIA Holdings Inc. IQV 46266C105 Health Care 234,816 $61,693,207.68 3.72%
QIAGEN N.V. QGEN N72482123 Health Care 1,131,898 $61,756,354.88 3.72%
Gilead Sciences, Inc. GILD 375558103 Health Care 864,034 $60,197,248.78 3.63%
Incyte Corporation INCY 45337C102 Health Care 891,430 $59,395,980.90 3.58%
United Therapeutics Corporation UTHR 91307C102 Health Care 312,218 $59,099,745.22 3.56%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 694,011 $57,734,775.09 3.48%
Ultragenyx Pharmaceutical Inc. RARE 90400D108 Health Care 730,537 $57,800,087.44 3.48%
Amgen Inc. AMGN 031162100 Health Care 281,344 $56,597,972.48 3.41%
bluebird bio, Inc. BLUE 09609G100 Health Care 5,181,504 $55,079,387.52 3.32%
Bio-Techne Corporation TECH 09073M104 Health Care 117,408 $54,861,236.16 3.31%
Moderna, Inc. MRNA 60770K107 Health Care 180,460 $54,406,885.40 3.28%
Seagen Inc. SGEN 81181C104 Health Care 338,308 $53,679,330.36 3.24%
Charles River Laboratories International, Inc. CRL 159864107 Health Care 144,803 $52,992,105.88 3.19%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 280,039 $51,205,131.15 3.09%
Illumina, Inc. ILMN 452327109 Health Care 142,629 $50,987,014.92 3.07%
Exact Sciences Corporation EXAS 30063P105 Health Care 590,518 $47,578,035.26 2.87%
Biogen Inc. BIIB 09062X103 Health Care 207,855 $47,499,024.60 2.86%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 559,209 $45,094,613.76 2.72%
Exelixis, Inc. EXEL 30161Q104 Health Care 2,678,637 $44,143,937.76 2.66%
Agios Pharmaceuticals, Inc. AGIO 00847X104 Health Care 1,262,786 $43,982,836.38 2.65%
Ionis Pharmaceuticals, Inc. IONS 462222100 Health Care 1,665,017 $43,540,194.55 2.62%
Grifols, S.A. (ADR) GRFS 398438408 Health Care 4,110,143 $42,827,690.06 2.58%
Alkermes Plc ALKS G01767105 Health Care 1,845,477 $40,803,496.47 2.46%
Nektar Therapeutics NKTR 640268108 Health Care 3,376,561 $38,526,561.01 2.32%
US Dollar $USD Other 1,481,156 $1,481,155.51 0.09%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.