First Trust NYSE Arca Biotechnology Index Fund (FBT)
Holdings of the Fund as of 7/6/2020

Total Number of Holdings (excluding cash): 30

Security Name Identifier Classification Shares / Quantity Market Value Weighting Descending sort
Ultragenyx Pharmaceutical Inc. RARE Health Care 1,112,235 $96,486,386.25 4.37%
BioMarin Pharmaceutical Inc. BMRN Health Care 730,957 $93,350,518.47 4.22%
Sarepta Therapeutics, Inc. SRPT Health Care 549,271 $89,800,315.79 4.06%
Neurocrine Biosciences, Inc. NBIX Health Care 658,282 $84,036,280.12 3.80%
Bio-Techne Corporation TECH Health Care 304,389 $82,139,371.65 3.72%
Charles River Laboratories International, Inc. CRL Health Care 449,213 $81,666,923.40 3.69%
Seattle Genetics, Inc. SGEN Health Care 476,069 $81,145,961.05 3.67%
Nektar Therapeutics NKTR Health Care 3,351,978 $80,380,432.44 3.64%
Agios Pharmaceuticals, Inc. AGIO Health Care 1,435,057 $78,712,876.45 3.56%
Alkermes Plc ALKS Health Care 3,981,295 $78,152,820.85 3.54%
Illumina, Inc. ILMN Health Care 205,911 $78,120,574.29 3.53%
Exact Sciences Corporation EXAS Health Care 872,619 $77,671,817.19 3.51%
Exelixis, Inc. EXEL Health Care 3,350,398 $77,528,209.72 3.51%
United Therapeutics Corporation UTHR Health Care 622,472 $74,099,066.88 3.35%
Ionis Pharmaceuticals, Inc. IONS Health Care 1,182,802 $71,884,791.76 3.25%
Alnylam Pharmaceuticals, Inc. ALNY Health Care 470,278 $71,684,475.54 3.24%
Regeneron Pharmaceuticals, Inc. REGN Health Care 114,279 $71,681,502.75 3.24%
ACADIA Pharmaceuticals Inc. ACAD Health Care 1,331,838 $71,506,382.22 3.23%
Alexion Pharmaceuticals, Inc. ALXN Health Care 629,319 $71,471,758.83 3.23%
IQVIA Holdings Inc. IQV Health Care 495,028 $71,105,821.92 3.22%
Amgen Inc. AMGN Health Care 277,006 $70,982,787.50 3.21%
FibroGen, Inc. FGEN Health Care 1,640,968 $70,774,949.84 3.20%
Incyte Corporation INCY Health Care 651,437 $70,218,394.23 3.18%
Vertex Pharmaceuticals Incorporated VRTX Health Care 240,667 $70,108,703.77 3.17%
QIAGEN N.V. QGEN Health Care 1,605,684 $69,461,889.84 3.14%
bluebird bio, Inc. BLUE Health Care 1,169,110 $67,901,908.80 3.07%
Gilead Sciences, Inc. GILD Health Care 775,720 $59,544,267.20 2.69%
Grifols, S.A. (ADR) GRFS Health Care 3,113,414 $59,310,536.70 2.68%
Biogen Inc. BIIB Health Care 190,113 $51,292,487.40 2.32%
Intercept Pharmaceuticals, Inc. ICPT Health Care 801,526 $36,950,348.60 1.67%
US Dollar $USD Other 1,252,761 $1,252,760.82 0.06%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.