First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 11/23/2022

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Moderna, Inc. MRNA 60770K107 Health Care 332,849 $58,851,031.69 4.13%
Grifols, S.A. (ADR) GRFS 398438408 Health Care 7,024,860 $57,814,597.80 4.06%
Exact Sciences Corporation EXAS 30063P105 Health Care 1,299,791 $56,007,994.19 3.93%
Gilead Sciences, Inc. GILD 375558103 Health Care 630,051 $53,818,956.42 3.78%
Mettler-Toledo International Inc. MTD 592688105 Health Care 36,370 $52,420,808.40 3.68%
IQVIA Holdings Inc. IQV 46266C105 Health Care 239,748 $52,197,934.56 3.66%
United Therapeutics Corporation UTHR 91307C102 Health Care 194,761 $51,973,920.46 3.65%
Charles River Laboratories International, Inc. CRL 159864107 Health Care 213,364 $51,437,793.12 3.61%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,156,857 $50,878,570.86 3.57%
BioNTech SE (ADR) BNTX 09075V102 Health Care 324,454 $50,689,448.42 3.56%
Bio-Techne Corporation TECH 09073M104 Health Care 150,769 $50,706,630.08 3.56%
QIAGEN N.V. QGEN N72482123 Health Care 1,012,833 $49,527,533.70 3.48%
Biogen Inc. BIIB 09062X103 Health Care 159,600 $48,430,620.00 3.40%
Amgen Inc. AMGN 031162100 Health Care 169,529 $48,044,518.60 3.37%
Incyte Corporation INCY 45337C102 Health Care 605,145 $47,056,075.20 3.30%
Alkermes Plc ALKS G01767105 Health Care 1,918,740 $46,567,819.80 3.27%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 474,515 $46,402,821.85 3.26%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 384,993 $45,802,617.21 3.22%
Agios Pharmaceuticals, Inc. AGIO 00847X104 Health Care 1,581,895 $45,606,032.85 3.20%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 142,371 $45,012,015.36 3.16%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 214,759 $44,775,103.91 3.14%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 59,827 $43,994,382.72 3.09%
Exelixis, Inc. EXEL 30161Q104 Health Care 2,596,422 $43,775,674.92 3.07%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 378,981 $43,484,279.94 3.05%
Illumina, Inc. ILMN 452327109 Health Care 194,133 $43,113,056.64 3.03%
Seagen Inc. SGEN 81181C104 Health Care 331,505 $41,093,359.80 2.89%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,689,619 $40,344,285.00 2.83%
Ionis Pharmaceuticals, Inc. IONS 462222100 Health Care 950,193 $39,195,461.25 2.75%
Ultragenyx Pharmaceutical Inc. RARE 90400D108 Health Care 1,109,669 $38,383,450.71 2.69%
FibroGen, Inc. FGEN 31572Q808 Health Care 2,604,338 $36,408,645.24 2.56%
US Dollar $USD Other 525,258 $525,258.03 0.04%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.