First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 4/30/2025

Total Number of Holdings (excluding cash): 76

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 74,421 $21,793,445.64 2.44%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 554,453 $21,706,834.95 2.43%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 151,248 $21,620,901.60 2.42%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 147,138 $20,789,128.02 2.33%
The Cigna Group CI 125523100 Health Care Providers 60,960 $20,728,838.40 2.32%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 355,722 $20,233,467.36 2.27%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 61,567 $20,133,024.67 2.25%
Centene Corporation CNC 15135B101 Health Care Providers 333,773 $19,976,314.05 2.24%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 65,752 $19,928,773.68 2.23%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 76,666 $19,342,065.14 2.17%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 107,431 $19,022,807.17 2.13%
Jazz Pharmaceuticals Plc JAZZ G50871105 Pharmaceuticals and Biotechnology 161,427 $18,880,501.92 2.11%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 152,823 $18,503,808.84 2.07%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 1,949,439 $18,480,681.72 2.07%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 114,766 $17,321,632.38 1.94%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Pharmaceuticals and Biotechnology 33,300 $16,966,350.00 1.90%
Premier, Inc. (Class A) PINC 74051N102 Health Care Providers 828,616 $16,862,335.60 1.89%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 63,108 $16,612,549.92 1.86%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 46,686 $16,110,404.88 1.80%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 657,759 $16,055,897.19 1.80%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 122,574 $16,026,550.50 1.79%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 674,127 $15,774,571.80 1.77%
Viatris Inc. VTRS 92556V106 Pharmaceuticals and Biotechnology 1,876,903 $15,803,523.26 1.77%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 26,159 $15,662,962.84 1.75%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 52,593 $15,300,355.56 1.71%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 262,972 $15,304,970.40 1.71%
DaVita Inc. DVA 23918K108 Health Care Providers 106,259 $15,040,961.45 1.68%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 143,641 $14,802,205.05 1.66%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 1,142,347 $14,770,546.71 1.65%
Encompass Health Corporation EHC 29261A100 Health Care Providers 119,533 $13,984,165.67 1.57%
Eli Lilly and Company LLY 532457108 Pharmaceuticals and Biotechnology 15,034 $13,514,814.30 1.51%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 1,021,603 $13,270,622.97 1.49%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 71,515 $12,745,403.30 1.43%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 388,389 $12,746,926.98 1.43%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 24,388 $12,579,330.40 1.41%
Labcorp Holdings Inc. LH 504922105 Medical Equipment and Services 52,035 $12,540,955.35 1.40%
Veeva Systems Inc. (Class A) VEEV 922475108 Health Care Providers 53,121 $12,413,846.49 1.39%
Stryker Corporation SYK 863667101 Medical Equipment and Services 32,432 $12,126,973.44 1.36%
Elevance Health Inc. ELV 036752103 Health Care Providers 27,980 $11,767,828.40 1.32%
Masimo Corporation MASI 574795100 Medical Equipment and Services 72,228 $11,625,818.88 1.30%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 136,806 $11,595,676.56 1.30%
AbbVie Inc. ABBV 00287Y109 Pharmaceuticals and Biotechnology 58,686 $11,449,638.60 1.28%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 175,274 $11,387,551.78 1.28%
Chemed Corporation CHE 16359R103 Health Care Providers 19,568 $11,378,987.68 1.27%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 23,140 $9,520,721.60 1.07%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 51,059 $8,848,524.70 0.99%
ResMed Inc. RMD 761152107 Medical Equipment and Services 36,306 $8,589,636.54 0.96%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 112,300 $8,477,527.00 0.95%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 132,498 $8,302,324.68 0.93%
The Cooper Companies, Inc. COO 216648501 Medical Equipment and Services 99,297 $8,109,585.99 0.91%
Humana Inc. HUM 444859102 Health Care Providers 30,487 $7,994,910.88 0.90%
Steris Plc STE G8473T100 Medical Equipment and Services 35,756 $8,035,803.44 0.90%
West Pharmaceutical Services, Inc. WST 955306105 Medical Equipment and Services 36,659 $7,745,680.11 0.87%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 70,762 $7,613,991.20 0.85%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Pharmaceuticals and Biotechnology 118,793 $7,565,926.17 0.85%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 35,702 $7,393,527.18 0.83%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 47,133 $7,308,914.31 0.82%
Revvity, Inc. RVTY 714046109 Medical Equipment and Services 77,373 $7,228,959.39 0.81%
GE HealthCare Technologies Inc. GEHC 36266G107 Medical Equipment and Services 101,429 $7,133,501.57 0.80%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 16,714 $7,170,306.00 0.80%
Certara, Inc. CERT 15687V109 Medical Equipment and Services 383,295 $5,312,468.70 0.60%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 56,199 $4,011,484.62 0.45%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 9,039 $3,910,723.35 0.44%
Medpace Holdings, Inc. MEDP 58506Q109 Pharmaceuticals and Biotechnology 12,705 $3,918,094.95 0.44%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 24,690 $3,859,293.90 0.43%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 35,354 $3,807,272.26 0.43%
Bruker Corporation BRKR 116794108 Medical Equipment and Services 93,691 $3,753,261.46 0.42%
Danaher Corporation DHR 235851102 Medical Equipment and Services 18,876 $3,762,553.08 0.42%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 51,550 $3,699,743.50 0.41%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 26,968 $3,695,964.40 0.41%
Waters Corporation WAT 941848103 Medical Equipment and Services 10,627 $3,695,326.71 0.41%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 23,366 $3,654,442.40 0.41%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 136,572 $3,512,631.84 0.39%
Bio-Techne Corporation TECH 09073M104 Medical Equipment and Services 65,963 $3,321,237.05 0.37%
Solventum Corporation SOLV 83444M101 Medical Equipment and Services 49,556 $3,276,642.72 0.37%
Charles River Laboratories International, Inc. CRL 159864107 Pharmaceuticals and Biotechnology 25,917 $3,074,274.54 0.34%
US Dollar $USD Other 854,397 $854,396.53 0.10%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.