First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 12/12/2025

Total Number of Holdings (excluding cash): 76

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Insmed Incorporated INSM 457669307 Pharmaceuticals and Biotechnology 139,111 $27,406,258.11 2.89%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 35,629 $26,411,421.41 2.78%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 143,013 $24,898,563.30 2.62%
Ionis Pharmaceuticals, Inc. IONS 462222100 Pharmaceuticals and Biotechnology 306,226 $24,749,185.32 2.61%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 279,843 $24,262,388.10 2.56%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 47,789 $23,607,288.11 2.49%
Centene Corporation CNC 15135B101 Health Care Providers 561,472 $22,936,131.20 2.42%
Illumina, Inc. ILMN 452327109 Pharmaceuticals and Biotechnology 168,754 $22,759,851.98 2.40%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 236,213 $22,537,082.33 2.37%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 97,991 $21,812,796.60 2.30%
Medpace Holdings, Inc. MEDP 58506Q109 Pharmaceuticals and Biotechnology 38,963 $21,737,457.70 2.29%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 786,237 $20,324,226.45 2.14%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Pharmaceuticals and Biotechnology 369,891 $19,718,889.21 2.08%
Merck & Co., Inc. MRK 58933Y105 Pharmaceuticals and Biotechnology 190,952 $19,152,485.60 2.02%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 37,603 $18,228,806.31 1.92%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 1,605,233 $17,930,452.61 1.89%
Elevance Health Inc. ELV 036752103 Health Care Providers 49,600 $17,809,872.00 1.88%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 104,689 $17,640,096.50 1.86%
Tempus AI, Inc. (Class A) TEM 88023B103 Pharmaceuticals and Biotechnology 248,213 $17,526,319.93 1.85%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 114,166 $17,444,564.80 1.84%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 795,762 $16,941,772.98 1.78%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 130,979 $16,618,615.52 1.75%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 95,991 $15,879,791.13 1.67%
The Cigna Group CI 125523100 Health Care Providers 55,600 $15,273,320.00 1.61%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 119,656 $15,012,041.76 1.58%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 162,707 $14,902,334.13 1.57%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 35,146 $13,972,292.30 1.47%
Bristol-Myers Squibb Company BMY 110122108 Pharmaceuticals and Biotechnology 266,518 $13,968,208.38 1.47%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 181,105 $13,863,587.75 1.46%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 64,825 $13,715,673.50 1.44%
Halozyme Therapeutics, Inc. HALO 40637H109 Pharmaceuticals and Biotechnology 218,525 $13,594,440.25 1.43%
GE HealthCare Technologies Inc. GEHC 36266G107 Medical Equipment and Services 160,053 $13,438,049.88 1.42%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 18,814 $13,248,818.80 1.40%
Bio-Rad Laboratories, Inc. (Class A) BIO 090572207 Medical Equipment and Services 42,869 $13,209,224.97 1.39%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 340,703 $13,079,588.17 1.38%
Humana Inc. HUM 444859102 Health Care Providers 46,200 $12,402,390.00 1.31%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 291,041 $11,897,756.08 1.25%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 34,810 $11,899,450.40 1.25%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 59,200 $11,804,480.00 1.24%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 809,099 $11,553,933.72 1.22%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 63,070 $11,514,059.20 1.21%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 1,500,622 $10,759,459.74 1.13%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 51,054 $10,117,881.72 1.07%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 219,093 $9,607,228.05 1.01%
The Cooper Companies, Inc. COO 216648501 Medical Equipment and Services 116,881 $9,593,592.48 1.01%
Revvity, Inc. RVTY 714046109 Medical Equipment and Services 91,424 $9,187,197.76 0.97%
Veeva Systems Inc. (Class A) VEEV 922475108 Health Care Providers 40,348 $9,008,094.48 0.95%
Apellis Pharmaceuticals, Inc. APLS 03753U106 Pharmaceuticals and Biotechnology 354,102 $8,933,993.46 0.94%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 118,733 $8,904,975.00 0.94%
Gilead Sciences, Inc. GILD 375558103 Pharmaceuticals and Biotechnology 72,192 $8,691,916.80 0.92%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 42,813 $8,600,703.57 0.91%
Sotera Health Company SHC 83601L102 Medical Equipment and Services 509,429 $8,573,690.07 0.90%
Corcept Therapeutics Inc. CORT 218352102 Pharmaceuticals and Biotechnology 96,419 $8,483,907.81 0.89%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 84,138 $8,402,862.06 0.88%
QIAGEN N.V. QGEN N72482206 Medical Equipment and Services 179,350 $8,110,207.00 0.85%
AbbVie Inc. ABBV 00287Y109 Pharmaceuticals and Biotechnology 34,609 $7,728,881.88 0.81%
Chemed Corporation CHE 16359R103 Health Care Providers 17,898 $7,697,213.88 0.81%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 25,955 $7,674,893.50 0.81%
ResMed Inc. RMD 761152107 Medical Equipment and Services 29,275 $7,385,204.25 0.78%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 539,739 $7,092,170.46 0.75%
Exact Sciences Corporation EXAS 30063P105 Pharmaceuticals and Biotechnology 68,657 $6,968,685.50 0.73%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 23,334 $5,412,321.30 0.57%
Waters Corporation WAT 941848103 Medical Equipment and Services 12,529 $4,827,799.57 0.51%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 14,828 $4,626,632.56 0.49%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 7,745 $4,432,308.60 0.47%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 19,776 $4,395,413.76 0.46%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 13,311 $4,229,437.14 0.45%
Sarepta Therapeutics, Inc. SRPT 803607100 Pharmaceuticals and Biotechnology 194,927 $4,196,778.31 0.44%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 29,265 $4,087,735.20 0.43%
Envista Holdings Corporation NVST 29415F104 Medical Equipment and Services 184,401 $4,051,289.97 0.43%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 48,300 $4,012,764.00 0.42%
Steris Plc STE G8473T100 Medical Equipment and Services 15,180 $3,822,172.20 0.40%
Labcorp Holdings Inc. LH 504922105 Medical Equipment and Services 13,085 $3,456,795.30 0.36%
Baxter International Inc. BAX 071813109 Medical Equipment and Services 164,964 $3,159,060.60 0.33%
Encompass Health Corporation EHC 29261A100 Health Care Providers 29,572 $3,164,204.00 0.33%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 25,672 $3,046,239.52 0.32%
US Dollar $USD Other 473,416 $473,415.89 0.05%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.