First Trust Health Care AlphaDEX® Fund (FXH)
Holdings of the Fund as of 9/16/2025

Total Number of Holdings (excluding cash): 76

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Insmed Incorporated INSM 457669307 Pharmaceuticals and Biotechnology 193,615 $28,025,771.25 3.06%
United Therapeutics Corporation UTHR 91307C102 Pharmaceuticals and Biotechnology 67,812 $26,987,141.64 2.95%
Tempus AI, Inc. (Class A) TEM 88023B103 Pharmaceuticals and Biotechnology 306,664 $26,692,034.56 2.92%
Elanco Animal Health Incorporated ELAN 28414H103 Pharmaceuticals and Biotechnology 1,364,536 $25,421,305.68 2.78%
Jazz Pharmaceuticals Plc JAZZ G50871105 Pharmaceuticals and Biotechnology 183,619 $23,235,148.26 2.54%
Biogen Inc. BIIB 09062X103 Pharmaceuticals and Biotechnology 155,153 $22,292,383.04 2.44%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Pharmaceuticals and Biotechnology 47,803 $22,048,655.72 2.41%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Pharmaceuticals and Biotechnology 37,113 $21,342,201.78 2.33%
Zimmer Biomet Holdings, Inc. ZBH 98956P102 Medical Equipment and Services 213,635 $21,175,501.20 2.32%
Universal Health Services, Inc. (Class B) UHS 913903100 Health Care Providers 107,568 $20,035,615.68 2.19%
Merck & Co., Inc. MRK 58933Y105 Pharmaceuticals and Biotechnology 246,152 $19,960,465.68 2.18%
Acadia Healthcare Company, Inc. ACHC 00404A109 Health Care Providers 858,774 $18,643,983.54 2.04%
Avantor, Inc. AVTR 05352A100 Medical Equipment and Services 1,447,665 $18,399,822.15 2.01%
Johnson & Johnson JNJ 478160104 Pharmaceuticals and Biotechnology 102,052 $18,008,095.92 1.97%
Humana Inc. HUM 444859102 Health Care Providers 63,763 $17,363,940.16 1.90%
Exelixis, Inc. EXEL 30161Q104 Pharmaceuticals and Biotechnology 442,100 $17,303,794.00 1.89%
Cardinal Health, Inc. CAH 14149Y108 Pharmaceuticals and Biotechnology 115,987 $17,208,991.19 1.88%
UnitedHealth Group Incorporated UNH 91324P102 Health Care Providers 49,966 $16,977,447.48 1.86%
Organon & Co. OGN 68622V106 Pharmaceuticals and Biotechnology 1,610,377 $16,683,505.72 1.82%
Insulet Corporation PODD 45784P101 Medical Equipment and Services 49,614 $16,478,297.82 1.80%
HCA Healthcare, Inc. HCA 40412C101 Health Care Providers 40,689 $16,265,427.75 1.78%
Natera, Inc. NTRA 632307104 Medical Equipment and Services 92,272 $16,148,522.72 1.77%
Pfizer Inc. PFE 717081103 Pharmaceuticals and Biotechnology 643,089 $15,369,827.10 1.68%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Pharmaceuticals and Biotechnology 283,581 $15,296,359.14 1.67%
Abbott Laboratories ABT 002824100 Medical Equipment and Services 114,613 $15,216,021.88 1.66%
Veeva Systems Inc. (Class A) VEEV 922475108 Health Care Providers 54,132 $14,825,672.16 1.62%
Boston Scientific Corporation BSX 101137107 Medical Equipment and Services 145,129 $14,364,868.42 1.57%
Incyte Corporation INCY 45337C102 Pharmaceuticals and Biotechnology 171,678 $14,403,784.20 1.57%
IDEXX Laboratories, Inc. IDXX 45168D104 Medical Equipment and Services 21,798 $14,073,878.70 1.54%
The Cigna Group CI 125523100 Health Care Providers 47,155 $13,873,472.55 1.52%
Doximity, Inc. (Class A) DOCS 26622P107 Health Care Providers 190,598 $13,738,303.84 1.50%
Medtronic Plc MDT G5960L103 Medical Equipment and Services 134,119 $12,632,668.61 1.38%
Elevance Health Inc. ELV 036752103 Health Care Providers 40,078 $12,424,180.00 1.36%
Teleflex Incorporated TFX 879369106 Medical Equipment and Services 98,780 $12,428,499.60 1.36%
ResMed Inc. RMD 761152107 Medical Equipment and Services 45,316 $12,353,141.60 1.35%
GE HealthCare Technologies Inc. GEHC 36266G107 Medical Equipment and Services 157,842 $12,229,598.16 1.34%
Tenet Healthcare Corporation THC 88033G407 Health Care Providers 66,428 $12,144,366.96 1.33%
Bristol-Myers Squibb Company BMY 110122108 Pharmaceuticals and Biotechnology 252,570 $11,704,093.80 1.28%
Gilead Sciences, Inc. GILD 375558103 Pharmaceuticals and Biotechnology 105,451 $11,690,297.86 1.28%
Quest Diagnostics Incorporated DGX 74834L100 Medical Equipment and Services 65,086 $11,725,893.76 1.28%
Exact Sciences Corporation EXAS 30063P105 Pharmaceuticals and Biotechnology 220,009 $11,647,276.46 1.27%
Royalty Pharma Plc (Class A) RPRX G7709Q104 Pharmaceuticals and Biotechnology 324,489 $11,493,400.38 1.26%
Centene Corporation CNC 15135B101 Health Care Providers 358,983 $11,415,659.40 1.25%
Corcept Therapeutics Inc. CORT 218352102 Pharmaceuticals and Biotechnology 159,283 $11,360,063.56 1.24%
IQVIA Holdings Inc. IQV 46266C105 Health Care Providers 49,457 $9,239,062.17 1.01%
Thermo Fisher Scientific Inc. TMO 883556102 Medical Equipment and Services 19,222 $9,240,784.28 1.01%
Becton, Dickinson and Company BDX 075887109 Medical Equipment and Services 45,248 $8,425,630.08 0.92%
Labcorp Holdings Inc. LH 504922105 Medical Equipment and Services 29,690 $8,137,732.10 0.89%
Penumbra, Inc. PEN 70975L107 Medical Equipment and Services 30,370 $7,986,095.20 0.87%
Encompass Health Corporation EHC 29261A100 Health Care Providers 63,559 $7,869,239.79 0.86%
Globus Medical, Inc. (Class A) GMED 379577208 Medical Equipment and Services 132,063 $7,638,523.92 0.84%
Hologic, Inc. HOLX 436440101 Medical Equipment and Services 119,616 $7,575,281.28 0.83%
Stryker Corporation SYK 863667101 Medical Equipment and Services 19,699 $7,419,037.38 0.81%
Henry Schein, Inc. HSIC 806407102 Medical Equipment and Services 106,699 $7,297,144.61 0.80%
Chemed Corporation CHE 16359R103 Health Care Providers 16,006 $7,164,765.78 0.78%
The Cooper Companies, Inc. COO 216648501 Medical Equipment and Services 109,532 $7,137,105.12 0.78%
Molina Healthcare, Inc. MOH 60855R100 Health Care Providers 39,247 $6,925,133.15 0.76%
Revvity, Inc. RVTY 714046109 Medical Equipment and Services 80,585 $6,872,288.80 0.75%
Masimo Corporation MASI 574795100 Medical Equipment and Services 46,334 $6,625,762.00 0.72%
Intuitive Surgical, Inc. ISRG 46120E602 Medical Equipment and Services 14,343 $6,232,033.50 0.68%
Halozyme Therapeutics, Inc. HALO 40637H109 Pharmaceuticals and Biotechnology 70,231 $5,327,021.35 0.58%
West Pharmaceutical Services, Inc. WST 955306105 Medical Equipment and Services 16,697 $4,313,669.95 0.47%
Neurocrine Biosciences, Inc. NBIX 64125C109 Pharmaceuticals and Biotechnology 29,068 $4,095,681.20 0.45%
Agilent Technologies, Inc. A 00846U101 Medical Equipment and Services 30,961 $3,937,929.59 0.43%
Steris Plc STE G8473T100 Medical Equipment and Services 15,209 $3,771,679.91 0.41%
Amgen Inc. AMGN 031162100 Pharmaceuticals and Biotechnology 13,088 $3,574,136.48 0.39%
Danaher Corporation DHR 235851102 Medical Equipment and Services 18,498 $3,523,314.06 0.39%
Solventum Corporation SOLV 83444M101 Medical Equipment and Services 48,174 $3,571,138.62 0.39%
Edwards Lifesciences Corporation EW 28176E108 Medical Equipment and Services 46,717 $3,507,979.53 0.38%
Zoetis Inc. ZTS 98978V103 Pharmaceuticals and Biotechnology 23,426 $3,454,397.96 0.38%
DaVita Inc. DVA 23918K108 Health Care Providers 25,647 $3,336,931.17 0.36%
DexCom, Inc. DXCM 252131107 Medical Equipment and Services 41,854 $3,203,923.70 0.35%
Waters Corporation WAT 941848103 Medical Equipment and Services 10,467 $3,172,338.36 0.35%
Summit Therapeutics Inc. SMMT 86627T108 Pharmaceuticals and Biotechnology 171,689 $3,111,004.68 0.34%
Perrigo Company Plc PRGO G97822103 Pharmaceuticals and Biotechnology 136,735 $2,922,026.95 0.32%
Align Technology, Inc. ALGN 016255101 Medical Equipment and Services 19,298 $2,543,862.36 0.28%
US Dollar $USD Other 2,309,289 $2,309,289.46 0.25%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.