First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 4/24/2025

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
BioNTech SE (ADR) BNTX 09075V102 Health Care 340,791 $41,078,947.14 3.93%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 644,584 $39,809,507.84 3.80%
Repligen Corporation RGEN 759916109 Health Care 267,728 $38,882,137.44 3.72%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 361,980 $38,283,004.80 3.66%
BeiGene, Ltd. (ADR) ONC 07725L102 Health Care 142,790 $36,577,086.40 3.50%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 578,900 $36,320,186.00 3.47%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,748,704 $35,918,380.16 3.43%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 59,355 $35,598,754.80 3.40%
Exelixis, Inc. EXEL 30161Q104 Health Care 931,553 $34,663,087.13 3.31%
United Therapeutics Corporation UTHR 91307C102 Health Care 116,991 $34,678,472.22 3.31%
Corcept Therapeutics Inc. CORT 218352102 Health Care 479,352 $34,412,680.08 3.29%
Moderna, Inc. MRNA 60770K107 Health Care 1,255,463 $34,387,131.57 3.29%
Waters Corporation WAT 941848103 Health Care 101,141 $34,458,738.70 3.29%
Natera, Inc. NTRA 632307104 Health Care 222,191 $34,324,065.68 3.28%
Biogen Inc. BIIB 09062X103 Health Care 285,605 $34,132,653.55 3.26%
Illumina, Inc. ILMN 452327109 Health Care 439,865 $34,137,922.65 3.26%
Incyte Corporation INCY 45337C102 Health Care 578,391 $34,107,717.27 3.26%
argenx SE (ADR) ARGX 04016X101 Health Care 56,621 $34,001,476.71 3.25%
Mettler-Toledo International Inc. MTD 592688105 Health Care 31,570 $33,937,750.00 3.24%
Exact Sciences Corporation EXAS 30063P105 Health Care 740,003 $33,744,136.80 3.23%
Alkermes Plc ALKS G01767105 Health Care 1,218,264 $33,709,364.88 3.22%
Gilead Sciences, Inc. GILD 375558103 Health Care 317,409 $33,692,965.35 3.22%
Krystal Biotech, Inc. KRYS 501147102 Health Care 199,352 $33,714,410.24 3.22%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 138,340 $33,562,667.40 3.21%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 2,256,044 $33,457,132.52 3.20%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 67,930 $33,453,487.10 3.20%
Veracyte, Inc. VCYT 92337F107 Health Care 1,034,375 $33,244,812.50 3.18%
Bruker Corporation BRKR 116794108 Health Care 848,636 $33,071,344.92 3.16%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 546,288 $32,367,564.00 3.09%
Amgen Inc. AMGN 031162100 Health Care 115,019 $32,186,916.96 3.08%
US Dollar $USD Other 409,759 $409,758.57 0.04%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.