First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 2/18/2026

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Moderna, Inc. MRNA 60770K107 Health Care 2,382,500 $111,024,500.00 4.61%
Gilead Sciences, Inc. GILD 375558103 Health Care 674,832 $103,073,839.68 4.28%
Amgen Inc. AMGN 031162100 Health Care 250,565 $95,147,047.45 3.95%
Krystal Biotech, Inc. KRYS 501147102 Health Care 312,599 $88,556,170.71 3.68%
BioNTech SE (ADR) BNTX 09075V102 Health Care 818,432 $88,349,734.40 3.67%
Alkermes Plc ALKS G01767105 Health Care 2,755,157 $88,220,127.14 3.66%
argenx SE (ADR) ARGX 04016X101 Health Care 103,683 $87,648,424.05 3.64%
BeOne Medicines Ltd. (ADR) ONC 07725L102 Health Care 241,840 $86,832,652.00 3.61%
Corcept Therapeutics Inc. CORT 218352102 Health Care 2,179,174 $86,774,708.68 3.60%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 1,386,199 $85,708,684.17 3.56%
Biogen Inc. BIIB 09062X103 Health Care 435,558 $84,554,874.54 3.51%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 176,141 $82,840,873.71 3.44%
Exact Sciences Corporation EXAS 30063P105 Health Care 800,328 $82,721,902.08 3.43%
Exelixis, Inc. EXEL 30161Q104 Health Care 1,855,578 $82,517,553.66 3.43%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 1,127,615 $82,575,246.45 3.43%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 102,592 $81,269,278.72 3.37%
United Therapeutics Corporation UTHR 91307C102 Health Care 169,063 $80,482,441.15 3.34%
Incyte Corporation INCY 45337C102 Health Care 764,648 $78,751,097.52 3.27%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 601,809 $77,260,239.42 3.21%
Natera, Inc. NTRA 632307104 Health Care 348,766 $75,169,535.98 3.12%
Bio-Techne Corporation TECH 09073M104 Health Care 1,243,870 $73,798,807.10 3.06%
Veracyte, Inc. VCYT 92337F107 Health Care 1,943,805 $71,162,701.05 2.95%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 3,051,470 $70,794,104.00 2.94%
Genmab A/S (ADR) GMAB 372303206 Health Care 2,385,267 $69,554,385.72 2.89%
Illumina, Inc. ILMN 452327109 Health Care 579,320 $69,570,538.80 2.89%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 205,179 $68,258,949.72 2.83%
Repligen Corporation RGEN 759916109 Health Care 489,850 $67,653,183.50 2.81%
NeoGenomics, Inc. NEO 64049M209 Health Care 6,209,626 $63,710,762.76 2.65%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 3,429,268 $63,029,945.84 2.62%
Bruker Corporation BRKR 116794108 Health Care 1,500,581 $59,663,100.56 2.48%
US Dollar $USD Other 1,591,946 $1,591,946.24 0.07%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.