First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 9/15/2025

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 108,129 $49,862,607.06 4.65%
United Therapeutics Corporation UTHR 91307C102 Health Care 115,234 $46,451,977.74 4.33%
argenx SE (ADR) ARGX 04016X101 Health Care 60,785 $46,003,911.55 4.29%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 595,872 $45,482,909.76 4.24%
BeOne Medicines Ltd. (ADR) ONC 07725L102 Health Care 136,053 $45,206,330.31 4.22%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,591,311 $44,540,794.89 4.16%
Incyte Corporation INCY 45337C102 Health Care 496,487 $41,277,929.18 3.85%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 1,623,168 $40,043,554.56 3.74%
Veracyte, Inc. VCYT 92337F107 Health Care 1,257,535 $40,077,640.45 3.74%
Natera, Inc. NTRA 632307104 Health Care 212,267 $36,543,886.72 3.41%
Biogen Inc. BIIB 09062X103 Health Care 253,737 $36,365,586.84 3.39%
Krystal Biotech, Inc. KRYS 501147102 Health Care 229,831 $35,786,985.01 3.34%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 255,163 $35,835,091.72 3.34%
Exact Sciences Corporation EXAS 30063P105 Health Care 656,022 $35,051,255.46 3.27%
Mettler-Toledo International Inc. MTD 592688105 Health Care 27,824 $35,061,857.12 3.27%
Gilead Sciences, Inc. GILD 375558103 Health Care 310,599 $34,954,811.46 3.26%
Illumina, Inc. ILMN 452327109 Health Care 343,115 $34,627,165.80 3.23%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 59,981 $34,344,520.79 3.20%
Corcept Therapeutics Inc. CORT 218352102 Health Care 473,763 $32,940,741.39 3.07%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 1,874,193 $32,742,151.71 3.05%
Amgen Inc. AMGN 031162100 Health Care 115,333 $31,647,375.20 2.95%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 586,129 $31,146,895.06 2.91%
Alkermes Plc ALKS G01767105 Health Care 1,124,640 $29,825,452.80 2.78%
Repligen Corporation RGEN 759916109 Health Care 261,572 $29,751,199.28 2.78%
Exelixis, Inc. EXEL 30161Q104 Health Care 759,119 $29,613,232.19 2.76%
BioNTech SE (ADR) BNTX 09075V102 Health Care 301,656 $29,526,089.28 2.75%
Waters Corporation WAT 941848103 Health Care 96,495 $28,855,864.80 2.69%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 72,634 $28,560,415.14 2.66%
Bruker Corporation BRKR 116794108 Health Care 777,668 $24,939,812.76 2.33%
Moderna, Inc. MRNA 60770K107 Health Care 1,012,308 $24,173,915.04 2.26%
US Dollar $USD Other 584,344 $584,344.20 0.05%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.