First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 12/19/2025

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Exact Sciences Corporation EXAS 30063P105 Health Care 672,986 $68,523,434.52 4.99%
Illumina, Inc. ILMN 452327109 Health Care 418,360 $56,386,560.80 4.11%
Natera, Inc. NTRA 632307104 Health Care 231,948 $53,802,658.08 3.92%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 69,535 $53,400,098.60 3.89%
ACADIA Pharmaceuticals Inc. ACAD 004225108 Health Care 1,957,224 $53,158,203.84 3.87%
Krystal Biotech, Inc. KRYS 501147102 Health Care 216,354 $52,098,043.20 3.79%
Bruker Corporation BRKR 116794108 Health Care 1,112,868 $51,726,104.64 3.77%
Moderna, Inc. MRNA 60770K107 Health Care 1,463,361 $49,461,601.80 3.60%
Veracyte, Inc. VCYT 92337F107 Health Care 1,128,218 $48,423,116.56 3.53%
Incyte Corporation INCY 45337C102 Health Care 468,520 $48,112,318.80 3.50%
Biogen Inc. BIIB 09062X103 Health Care 267,876 $46,824,724.80 3.41%
United Therapeutics Corporation UTHR 91307C102 Health Care 89,234 $46,145,578.42 3.36%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 750,418 $45,888,060.70 3.34%
Exelixis, Inc. EXEL 30161Q104 Health Care 1,029,501 $45,606,894.30 3.32%
Waters Corporation WAT 941848103 Health Care 118,620 $44,841,918.60 3.26%
Corcept Therapeutics Inc. CORT 218352102 Health Care 530,853 $44,464,247.28 3.24%
Amgen Inc. AMGN 031162100 Health Care 135,325 $44,302,698.50 3.23%
Repligen Corporation RGEN 759916109 Health Care 270,328 $43,895,860.64 3.20%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 96,277 $43,921,567.40 3.20%
Mettler-Toledo International Inc. MTD 592688105 Health Care 30,826 $43,233,773.26 3.15%
argenx SE (ADR) ARGX 04016X101 Health Care 49,268 $42,123,647.32 3.07%
Gilead Sciences, Inc. GILD 375558103 Health Care 335,054 $41,643,861.66 3.03%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 287,363 $41,667,635.00 3.03%
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 612,510 $41,252,548.50 3.00%
Genmab A/S (ADR) GMAB 372303206 Health Care 1,234,265 $39,965,500.70 2.91%
BeOne Medicines Ltd. (ADR) ONC 07725L102 Health Care 122,657 $38,765,744.85 2.82%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 1,776,478 $37,377,097.12 2.72%
Alkermes Plc ALKS G01767105 Health Care 1,257,994 $35,789,929.30 2.61%
BioNTech SE (ADR) BNTX 09075V102 Health Care 384,694 $35,584,195.00 2.59%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 85,320 $34,147,623.60 2.49%
US Dollar $USD Other 1,013,845 $1,013,844.54 0.07%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.