First Trust NYSE® Arca® Biotechnology Index Fund (FBT)
Holdings of the Fund as of 9/18/2026

Total Number of Holdings (excluding cash): 30

Security Name Identifier CUSIP Classification Shares / Quantity Market Value Weighting Descending sort
Halozyme Therapeutics, Inc. HALO 40637H109 Health Care 1,188,143 $133,606,680.35 4.57%
NeoGenomics, Inc. NEO 64049M209 Health Care 6,416,474 $127,751,997.34 4.37%
Natera, Inc. NTRA 632307104 Health Care 335,386 $123,888,234.54 4.24%
Illumina, Inc. ILMN 452327109 Health Care 476,004 $114,060,078.48 3.90%
Repligen Corporation RGEN 759916109 Health Care 627,681 $111,030,492.09 3.80%
Corcept Therapeutics Inc. CORT 218352102 Health Care 985,377 $108,677,229.33 3.72%
Genmab A/S (ADR) GMAB 372303206 Health Care 3,121,944 $108,456,334.56 3.71%
Regeneron Pharmaceuticals, Inc. REGN 75886F107 Health Care 136,243 $106,930,318.55 3.66%
BeOne Medicines Ltd. (ADR) ONC 07725L102 Health Care 303,104 $106,341,007.36 3.64%
Gilead Sciences, Inc. GILD 375558103 Health Care 697,344 $104,678,307.84 3.58%
argenx SE (ADR) ARGX 04016X101 Health Care 103,163 $102,164,382.16 3.50%
Biogen Inc. BIIB 09062X103 Health Care 454,617 $97,969,963.50 3.35%
BioMarin Pharmaceutical Inc. BMRN 09061G101 Health Care 1,531,399 $97,917,652.06 3.35%
Incyte Corporation INCY 45337C102 Health Care 775,742 $97,208,230.02 3.33%
Amgen Inc. AMGN 031162100 Health Care 249,143 $96,081,997.95 3.29%
Sarepta Therapeutics, Inc. SRPT 803607100 Health Care 4,777,645 $96,078,440.95 3.29%
BioNTech SE (ADR) BNTX 09075V102 Health Care 989,580 $95,059,054.80 3.25%
Vertex Pharmaceuticals Incorporated VRTX 92532F100 Health Care 186,520 $94,815,576.80 3.24%
Exelixis, Inc. EXEL 30161Q104 Health Care 1,602,410 $93,516,647.60 3.20%
Bruker Corporation BRKR 116794108 Health Care 1,507,431 $92,541,189.09 3.17%
Bio-Techne Corporation TECH 09073M104 Health Care 1,269,793 $91,894,919.41 3.14%
ADMA Biologics, Inc. ADMA 000899104 Health Care 9,970,973 $90,835,564.03 3.11%
TG Therapeutics, Inc. TGTX 88322Q108 Health Care 1,585,019 $90,140,030.53 3.08%
Madrigal Pharmaceuticals, Inc. MDGL 558868105 Health Care 168,689 $89,661,577.28 3.07%
United Therapeutics Corporation UTHR 91307C102 Health Care 165,498 $81,860,275.74 2.80%
Axsome Therapeutics, Inc. AXSM 05464T104 Health Care 387,241 $80,460,934.98 2.75%
Alkermes Plc ALKS G01767105 Health Care 1,743,095 $75,632,892.05 2.59%
Neurocrine Biosciences, Inc. NBIX 64125C109 Health Care 511,187 $74,750,875.01 2.56%
Alnylam Pharmaceuticals, Inc. ALNY 02043Q107 Health Care 303,041 $72,596,501.96 2.48%
Veracyte, Inc. VCYT 92337F107 Health Care 1,589,193 $63,241,935.45 2.16%
US Dollar $USD Other 3,189,033 $3,189,033.15 0.11%
Holdings are subject to change.

The holdings information set forth above for the date indicated reflects creation and redemption transactions from the prior business day and may differ from the holdings information currently available from the Fund's custodian and accounting agent. With respect to the market value of the Fund's holdings set forth above, the pricing sources are generally third party vendors. The Fund ultimately relies on pricing information provided by the Fund's accounting agent.